Inactivation of some semisynthetic penicillins by gram-negative bacilli.

L. D. Sabath, M. FINLAND

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sabath, Leon (Boston City Hospital, Boston, Mass.) and Maxwell Finland. Inactivation of some semisynthetic penicillins by gram-negative bacilli. J. Bacteriol. 85:314-321. 1963.-An agar diffusion method was used to test 55 strains of gram-negative bacilli for their ability to inactivate penicillin G, methicillin, biphenylpenicillin, oxacillin, and ampicillin; 26 strains inactivated one or more of them. All strains of Klebsiella-Aerobacter, nearly all of Escherichia coli, and some of Pseudomonas aeruginosa, but not those of Proteus or Salmonella, were active by this method. Penicillin G was inactivated by the largest number of strains, biphenylpenicillin and ampicillin by somewhat fewer, and oxacillin and methicillin by about half as many. When the five penicillins were incubated with four strains of different bacteria in broth at 37 C, all were inactivated to a considerable extent by all the strains, each penicillin to a different degree, but to about the same extent by all the strains. Adsorption alone did not account for the loss of activity. The results suggest that there are qualitative, as well as quantitative, differences among species or even strains of gram-negative bacilli in their ability to inactivate the various penicillins.
Original languageUndefined/Unknown
Pages (from-to)314-321
Number of pages8
JournalJournal of Bacteriology
Volume85
StatePublished - 1963

Keywords

  • Ampicillin
  • Bacteria
  • Enterobacter
  • Escherichia coli
  • Finland
  • Gram-Negative Bacteria
  • Klebsiella
  • Methicillin
  • Oxacillin
  • Penicillin G
  • Penicillins
  • Proteus
  • Pseudomonas aeruginosa
  • Salmonella

Cite this

Inactivation of some semisynthetic penicillins by gram-negative bacilli. / Sabath, L. D.; FINLAND, M.

In: Journal of Bacteriology, Vol. 85, 1963, p. 314-321.

Research output: Contribution to journalArticle

Sabath, L. D. ; FINLAND, M. / Inactivation of some semisynthetic penicillins by gram-negative bacilli. In: Journal of Bacteriology. 1963 ; Vol. 85. pp. 314-321.
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AU - FINLAND, M.

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N2 - Sabath, Leon (Boston City Hospital, Boston, Mass.) and Maxwell Finland. Inactivation of some semisynthetic penicillins by gram-negative bacilli. J. Bacteriol. 85:314-321. 1963.-An agar diffusion method was used to test 55 strains of gram-negative bacilli for their ability to inactivate penicillin G, methicillin, biphenylpenicillin, oxacillin, and ampicillin; 26 strains inactivated one or more of them. All strains of Klebsiella-Aerobacter, nearly all of Escherichia coli, and some of Pseudomonas aeruginosa, but not those of Proteus or Salmonella, were active by this method. Penicillin G was inactivated by the largest number of strains, biphenylpenicillin and ampicillin by somewhat fewer, and oxacillin and methicillin by about half as many. When the five penicillins were incubated with four strains of different bacteria in broth at 37 C, all were inactivated to a considerable extent by all the strains, each penicillin to a different degree, but to about the same extent by all the strains. Adsorption alone did not account for the loss of activity. The results suggest that there are qualitative, as well as quantitative, differences among species or even strains of gram-negative bacilli in their ability to inactivate the various penicillins.

AB - Sabath, Leon (Boston City Hospital, Boston, Mass.) and Maxwell Finland. Inactivation of some semisynthetic penicillins by gram-negative bacilli. J. Bacteriol. 85:314-321. 1963.-An agar diffusion method was used to test 55 strains of gram-negative bacilli for their ability to inactivate penicillin G, methicillin, biphenylpenicillin, oxacillin, and ampicillin; 26 strains inactivated one or more of them. All strains of Klebsiella-Aerobacter, nearly all of Escherichia coli, and some of Pseudomonas aeruginosa, but not those of Proteus or Salmonella, were active by this method. Penicillin G was inactivated by the largest number of strains, biphenylpenicillin and ampicillin by somewhat fewer, and oxacillin and methicillin by about half as many. When the five penicillins were incubated with four strains of different bacteria in broth at 37 C, all were inactivated to a considerable extent by all the strains, each penicillin to a different degree, but to about the same extent by all the strains. Adsorption alone did not account for the loss of activity. The results suggest that there are qualitative, as well as quantitative, differences among species or even strains of gram-negative bacilli in their ability to inactivate the various penicillins.

KW - Ampicillin

KW - Bacteria

KW - Enterobacter

KW - Escherichia coli

KW - Finland

KW - Gram-Negative Bacteria

KW - Klebsiella

KW - Methicillin

KW - Oxacillin

KW - Penicillin G

KW - Penicillins

KW - Proteus

KW - Pseudomonas aeruginosa

KW - Salmonella

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JO - Journal of Bacteriology

JF - Journal of Bacteriology

SN - 0021-9193

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