Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism

Keyphrases

• Nicotine Metabolism 100%
• CYP2A6 100%
• CYP2A13 100%
• Nicotine 50%
• Cotinine 30%
• Tobacco 20%
• Metabolism 20%
• Trans-3′-hydroxycotinine 20%
• Enzyme Inactivation 20%
• Iminium Ion 20%
• Dialysis 10%
• Carcinogen 10%
• Mechanism-based 10%
• Enzyme Activity 10%
• Hydroxymethyl 10%
• Pyridyl 10%
• Metabolic Activation 10%
• Nicotinamide Adenine Dinucleotide Phosphate (NADPH) 10%
• Ultra-high Performance Liquid Chromatography (UHPLC) 10%
• Alternative Substrates 10%
• Aldehyde Oxidase 10%
• Short Reaction Time 10%
• Norcotinine 10%
• Primary Catalyst 10%
• 2-Butanone 10%

Pharmacology, Toxicology and Pharmaceutical Science

• CYP2A6 100%
• Cotinine 75%
• Carcinogen 25%
• NNK 25%
• 2 Butanone 25%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate 25%
• Hyperbarism 25%
• Aldehyde Oxidase 25%

Immunology and Microbiology

• Metabolite 100%
• Enzyme Inactivation 66%
• Liquid Chromatography 33%
• Enzyme Activity 33%
• Metabolic Activation 33%