In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: An initial experience

Hao Lei, Xiao-Hong Zhu, Xiao Liang Zhang, Kamil Ugurbil, Wei Chen

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

In vivo 3P spectra were acquired from the human primary visual cortex at 7 T. The relaxation times of the cerebral metabolites, intracellular pH, rate constant (kf) of the creatine kinase (CK) reaction, and nuclear Overhauser enhancement (NOE) on the detected phosphorus moieties from irradiation of the water spins were measured from normal subjects. With a 5-cm-diameter surface coil, 3D 31P chemical shift imaging was performed with a spatial resolution of 7.5 ml and an acquisition resolution of 8 min, resulting in a signal-to-noise ratio (SNR) for phosphocreatine (PCr) resonance of 32. The apparent T1 and T2 of PCr measured at 7 T were 3.37 ± 0.29 s and 132.0 ± 12.8 ms, respectively, which were considerably longer than those of adenosine triphosphate (ATP) (T1: 1.02-1.27 s; T2: 25-26 ms). The NOE measured in this study was 24.3% ± 1.6% for PCr, and 10% for ATP. The kf measured in the human primary visual cortex was 0.24 ± 0.03 s-1. The results from this study suggest that ultra-high-field strength is advantageous for performing in vivo 31P magnetic resonance spectroscopy (MRS) in the human brain.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalMagnetic resonance in medicine
Volume49
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Bioenergetics
  • High field
  • Human brain
  • Magnetic resonance spectroscopy
  • P MRS
  • Phosphorus

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