Abstract
In vivo proton NMR spectroscopy allows non-invasive detection and quantification of a wide range of biochemical compounds in the brain. Higher field strength is generally considered advantageous for spectroscopy due to increased signal-to-noise and increased spectral dispersion. So far 1H NMR spectra have been reported in the human brain up to 7 T. In this study we show that excellent quality short echo time STEAM and LASER 1H NMR spectra can be measured in the human brain at 9.4 T. The information content of the human brain spectra appears very similar to that measured in the past decade in rodent brains at the same field strength, in spite of broader linewidth in human brain. Compared to lower fields, the T 1 relaxation times of metabolites were slightly longer while T 2 relaxation values of metabolites were shorter (<100 ms) at 9.4 T. The linewidth of the total creatine (tCr) resonance at 3.03 ppm increased linearly with magnetic field (1.35 Hz/T from 1.5 T to 9.4 T), with a minimum achievable tCr linewidth of around 12.5 Hz at 9.4 T. At very high field, B 0 microsusceptibility effects are the main contributor to the minimum achievable linewidth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 74-80 |
| Number of pages | 7 |
| Journal | Journal of Magnetic Resonance |
| Volume | 206 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1 2010 |
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Keywords
- Brain
- Human
- Proton NMR spectroscopy
- Relaxation times
- Ultra-high field
Cite this
In vivo 1H NMR spectroscopy of the human brain at 9.4 T : Initial results. / Deelchand, Dinesh K; Van de Moortele, Pierre-Francois; Adriany, Gregor; Iltis, Isabelle; Andersen, Peter M; Strupp, John P; Vaughan, J. T; Uurbil, Kâmil; Henry, Pierre-Gilles.
In: Journal of Magnetic Resonance, Vol. 206, No. 1, 01.09.2010, p. 74-80.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo 1H NMR spectroscopy of the human brain at 9.4 T
T2 - Initial results
AU - Deelchand, Dinesh K
AU - Van de Moortele, Pierre-Francois
AU - Adriany, Gregor
AU - Iltis, Isabelle
AU - Andersen, Peter M
AU - Strupp, John P
AU - Vaughan, J. T
AU - Uurbil, Kâmil
AU - Henry, Pierre-Gilles
PY - 2010/9/1
Y1 - 2010/9/1
N2 - In vivo proton NMR spectroscopy allows non-invasive detection and quantification of a wide range of biochemical compounds in the brain. Higher field strength is generally considered advantageous for spectroscopy due to increased signal-to-noise and increased spectral dispersion. So far 1H NMR spectra have been reported in the human brain up to 7 T. In this study we show that excellent quality short echo time STEAM and LASER 1H NMR spectra can be measured in the human brain at 9.4 T. The information content of the human brain spectra appears very similar to that measured in the past decade in rodent brains at the same field strength, in spite of broader linewidth in human brain. Compared to lower fields, the T 1 relaxation times of metabolites were slightly longer while T 2 relaxation values of metabolites were shorter (<100 ms) at 9.4 T. The linewidth of the total creatine (tCr) resonance at 3.03 ppm increased linearly with magnetic field (1.35 Hz/T from 1.5 T to 9.4 T), with a minimum achievable tCr linewidth of around 12.5 Hz at 9.4 T. At very high field, B 0 microsusceptibility effects are the main contributor to the minimum achievable linewidth.
AB - In vivo proton NMR spectroscopy allows non-invasive detection and quantification of a wide range of biochemical compounds in the brain. Higher field strength is generally considered advantageous for spectroscopy due to increased signal-to-noise and increased spectral dispersion. So far 1H NMR spectra have been reported in the human brain up to 7 T. In this study we show that excellent quality short echo time STEAM and LASER 1H NMR spectra can be measured in the human brain at 9.4 T. The information content of the human brain spectra appears very similar to that measured in the past decade in rodent brains at the same field strength, in spite of broader linewidth in human brain. Compared to lower fields, the T 1 relaxation times of metabolites were slightly longer while T 2 relaxation values of metabolites were shorter (<100 ms) at 9.4 T. The linewidth of the total creatine (tCr) resonance at 3.03 ppm increased linearly with magnetic field (1.35 Hz/T from 1.5 T to 9.4 T), with a minimum achievable tCr linewidth of around 12.5 Hz at 9.4 T. At very high field, B 0 microsusceptibility effects are the main contributor to the minimum achievable linewidth.
KW - Brain
KW - Human
KW - Proton NMR spectroscopy
KW - Relaxation times
KW - Ultra-high field
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UR - http://www.scopus.com/inward/citedby.url?scp=77955917560&partnerID=8YFLogxK
U2 - 10.1016/j.jmr.2010.06.006
DO - 10.1016/j.jmr.2010.06.006
M3 - Article
C2 - 20598925
AN - SCOPUS:77955917560
VL - 206
SP - 74
EP - 80
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
SN - 1090-7807
IS - 1
ER -