In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

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Abstract

In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.

Original languageEnglish (US)
Pages (from-to)527-539
Number of pages13
JournalMagnetic Resonance Imaging
Volume24
Issue number4
DOIs
StatePublished - May 1 2006

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Keywords

  • C NMR spectroscopy
  • Compartmentation
  • Glutamatergic neurotransmission
  • Metabolic modeling
  • TCA cycle

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