In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

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Abstract

In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.

Original languageEnglish (US)
Pages (from-to)527-539
Number of pages13
JournalMagnetic Resonance Imaging
Volume24
Issue number4
DOIs
StatePublished - May 2006

Bibliographical note

Funding Information:
We would like to thank Dee Koski for technical assistance. This work was supported in part by NIH grants P41-RR08079, R01-NS38672, the Keck Foundation and the MIND Institute. The General Clinical Research Center was supported by NIH grant M01-RR00400.

Keywords

  • C NMR spectroscopy
  • Compartmentation
  • Glutamatergic neurotransmission
  • Metabolic modeling
  • TCA cycle

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