In vivo proton magnetic resonance spectroscopy of breast cancer: A review of the literature

Jonathan K.P. Begley, Thomas W. Redpath, Patrick J. Bolan, Fiona J. Gilbert

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


An emerging clinical modality called proton magnetic resonance spectroscopy ( 1H-MRS) enables the non-invasive in vivo assessment of tissue metabolism and is demonstrating applications in improving the specificity of MR breast lesion diagnosis and monitoring tumour responsiveness to neoadjuvant chemotherapies. Variations in the concentration of choline-based cellular metabolites, detectable with 1H-MRS, have shown an association with malignant transformation of tissue in in vivo and in vitro studies. 1H-MRS exists as an adjunct to the current routine clinical breast MR examination. This review serves as an introduction to the field of breast 1H-MRS, discusses modern high-field strength and quantitative approaches and technical considerations, and reviews the literature with respect to the application of 1H-MRS for breast cancer.

Original languageEnglish (US)
Article number207
JournalBreast Cancer Research
Issue number2
StatePublished - Apr 19 2012

Bibliographical note

Funding Information:
Dr Bolan wishes to acknowledge support from the NIH for the P41-RR008079 grant.


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