Abstract
An overview of the methodology background and the present status of in vivo O MR spectroscopy (MRS)/imaging (MRI) approach for imaging the cerebral metabolic rate of oxygen (CMRO 22) and studying the central roles of cerebral oxygen metabolism in brain function is presented. The brain is a highly aerobic organ; it consumes oxygen and glucose extensively in order to generate chemical energy in the form of the adenosine triphosphate (ATP) molecule. Oxygen and glucose as the major fuels for brain metabolism are continuously supplied by the circulating blood flow through the capillary bed. Unlike small animals, quantification of CMRO 2 in humans faces serious challenges. The human body size, lung capacity and respiration rate as well as blood circulation speed are drastically different from those in the small animal. It is expected that the exchange process between non-labeled and inhaled O-labeled oxygen gases in a human lung will be much slower compared to small animals such as a rat or mouse.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 319-335 |
| Number of pages | 17 |
| Journal | Progress in Nuclear Magnetic Resonance Spectroscopy |
| Volume | 59 |
| Issue number | 4 |
| DOIs | |
| State | Published - Nov 1 2011 |
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Keywords
- Brain
- Cerebral metabolic rate of oxygen utilization
- High field
- In vivo O NMR
- Oxidative metabolism
Cite this
In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field. / Zhu, Xiao Hong; Chen, Wei.
In: Progress in Nuclear Magnetic Resonance Spectroscopy, Vol. 59, No. 4, 01.11.2011, p. 319-335.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field
AU - Zhu, Xiao Hong
AU - Chen, Wei
PY - 2011/11/1
Y1 - 2011/11/1
N2 - An overview of the methodology background and the present status of in vivo O MR spectroscopy (MRS)/imaging (MRI) approach for imaging the cerebral metabolic rate of oxygen (CMRO 22) and studying the central roles of cerebral oxygen metabolism in brain function is presented. The brain is a highly aerobic organ; it consumes oxygen and glucose extensively in order to generate chemical energy in the form of the adenosine triphosphate (ATP) molecule. Oxygen and glucose as the major fuels for brain metabolism are continuously supplied by the circulating blood flow through the capillary bed. Unlike small animals, quantification of CMRO 2 in humans faces serious challenges. The human body size, lung capacity and respiration rate as well as blood circulation speed are drastically different from those in the small animal. It is expected that the exchange process between non-labeled and inhaled O-labeled oxygen gases in a human lung will be much slower compared to small animals such as a rat or mouse.
AB - An overview of the methodology background and the present status of in vivo O MR spectroscopy (MRS)/imaging (MRI) approach for imaging the cerebral metabolic rate of oxygen (CMRO 22) and studying the central roles of cerebral oxygen metabolism in brain function is presented. The brain is a highly aerobic organ; it consumes oxygen and glucose extensively in order to generate chemical energy in the form of the adenosine triphosphate (ATP) molecule. Oxygen and glucose as the major fuels for brain metabolism are continuously supplied by the circulating blood flow through the capillary bed. Unlike small animals, quantification of CMRO 2 in humans faces serious challenges. The human body size, lung capacity and respiration rate as well as blood circulation speed are drastically different from those in the small animal. It is expected that the exchange process between non-labeled and inhaled O-labeled oxygen gases in a human lung will be much slower compared to small animals such as a rat or mouse.
KW - Brain
KW - Cerebral metabolic rate of oxygen utilization
KW - High field
KW - In vivo O NMR
KW - Oxidative metabolism
UR - http://www.scopus.com/inward/record.url?scp=80054956519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054956519&partnerID=8YFLogxK
U2 - 10.1016/j.pnmrs.2011.04.002
DO - 10.1016/j.pnmrs.2011.04.002
M3 - Review article
C2 - 22027341
AN - SCOPUS:80054956519
VL - 59
SP - 319
EP - 335
JO - Progress in Nuclear Magnetic Resonance Spectroscopy
JF - Progress in Nuclear Magnetic Resonance Spectroscopy
SN - 0079-6565
IS - 4
ER -