In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

An overview of the methodology background and the present status of in vivo O MR spectroscopy (MRS)/imaging (MRI) approach for imaging the cerebral metabolic rate of oxygen (CMRO 22) and studying the central roles of cerebral oxygen metabolism in brain function is presented. The brain is a highly aerobic organ; it consumes oxygen and glucose extensively in order to generate chemical energy in the form of the adenosine triphosphate (ATP) molecule. Oxygen and glucose as the major fuels for brain metabolism are continuously supplied by the circulating blood flow through the capillary bed. Unlike small animals, quantification of CMRO 2 in humans faces serious challenges. The human body size, lung capacity and respiration rate as well as blood circulation speed are drastically different from those in the small animal. It is expected that the exchange process between non-labeled and inhaled O-labeled oxygen gases in a human lung will be much slower compared to small animals such as a rat or mouse.

Original languageEnglish (US)
Pages (from-to)319-335
Number of pages17
JournalProgress in Nuclear Magnetic Resonance Spectroscopy
Volume59
Issue number4
DOIs
StatePublished - Nov 1 2011

Fingerprint

oxygen metabolism
oxygen 17
Metabolism
brain
Brain
Magnetic Resonance Imaging
Nuclear magnetic resonance
Oxygen
animals
Imaging techniques
nuclear magnetic resonance
oxygen
Animals
glucose
lungs
blood circulation
Glucose
chemical energy
adenosine triphosphate
respiration

Keywords

  • Brain
  • Cerebral metabolic rate of oxygen utilization
  • High field
  • In vivo O NMR
  • Oxidative metabolism

Cite this

In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field. / Zhu, Xiao Hong; Chen, Wei.

In: Progress in Nuclear Magnetic Resonance Spectroscopy, Vol. 59, No. 4, 01.11.2011, p. 319-335.

Research output: Contribution to journalReview article

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