Noninvasive cognitive neuroimaging studies based on functional magnetic resonance imaging (fMRI) are of ever-increasing importance for basic and clinical neurosciences. The explanatory power of fMRI could be greatly expanded, however, if the pattern of the neuronal circuitry underlying functional activation could be made visible in an equally noninvasive manner. In this study, blood oxygenation level-dependent (BOLD)-based fMRI and diffusion tensor imaging (DTI) were performed in the same cat visual cortex, and the foci of fMRI activation utilized as seeding points for 3D DTI fiber reconstruction algorithms, thus providing the map of the axonal circuitry underlying visual information processing. The methods developed in this study will lay the foundation for in vivo neuroanatomy and the ability for noninvasive longitudinal studies of brain development.
|Original language||English (US)|
|Number of pages||10|
|Journal||Magnetic Resonance Imaging|
|State||Published - Dec 2003|
Bibliographical noteFunding Information:
The authors thank Drs. Mathieu Ducros and Christoph Kayser for their helpful discussions. Supported by the National Institutes of Health (Grant PR08079), The Keck Foundation, and the Human Frontiers Science Program.
- Visual cortex