Background: Mouse prostate cancer modeling presents unique obstacles to the study of spontaneous tumor initiation and progression due to the anatomical location of the tissue. Results: High resolution [130 microm(x) × 130 microm(y) × 300 microm(z)], three-dimensional MRI allowed for the visualization, segmentation, and volumetric measurement of the prostate from normal and genetically engineered animals, in vivo. Additionally, MRS performed on the prostate epithelia of probasin-ErbB-2Delta × Pten(+/-) mice identified changes in the relative concentrations of the metabolites choline and citrate, which was not observed in TRAMP mice. Methods: T1-weighted MRI was performed on normal, TRAMP, probasin-ErbB-2/Her2/Neu (probasin-ErbB-2Delta), and probasin-ErbB-2Delta in the context of decreased Pten activity [probasin-ErbB-2Delta × Pten(+/-)] mice. Volume-localized single-voxel proton magnetic resonance spectroscopy (SVS 1H-MRS) was also performed. Conclusions: The data presented supports the use of combined MRI and MRS for the measurement of biochemical and morphometric alterations in mouse models of prostate cancer.
|Original language||English (US)|
|Number of pages||1|
|Journal||Urologic Oncology: Seminars and Original Investigations|
|State||Published - Jul 1 2007|