In vivo human head MRI at 10.5T: A radiofrequency safety study and preliminary imaging results

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Purpose: The purpose of this study is to safely acquire the first human head images at 10.5T. Methods: To ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental (Formula presented.) and specific absorption rate (SAR). Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. We conducted all experiments and imaging sessions in a controlled radiofrequency safety lab and the whole-body 10.5T scanner in the Center for Magnetic Resonance Research. Results: Quantitative agreement between the simulated and experimental results was obtained including S-parameters, (Formula presented.) maps, and SAR. We calculated peak 10 g average SAR using 4 different realistic human body models for a quadrature excitation and demonstrated that the peak 10 g SAR variation between subjects was less than 30%. We calculated safe power limits based on this set and used those limits to acquire T2- and (Formula presented.) -weighted images of human subjects at 10.5T. Conclusions: In this study, we acquired the first in vivo human head images at 10.5T using an 8-channel transmit/receive coil. We implemented and expanded a previously proposed workflow to validate the electromagnetic simulation model of the 8-channel transmit/receive coil. Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects.

Original languageEnglish (US)
Pages (from-to)484-496
Number of pages13
JournalMagnetic resonance in medicine
Volume84
Issue number1
DOIs
StatePublished - Jul 1 2020

Bibliographical note

Publisher Copyright:
© 2019 International Society for Magnetic Resonance in Medicine

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • 10.5T
  • MRI
  • head imaging
  • radiofrequency safety
  • ultra-high field

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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