In vivo estimation of fatty acid synthesis in the chicken (Gallus domesticus) utilizing 3H2O

Linda Brady, Dale R. Romsos, Gilbert A. Leveille

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27 Scopus citations


1. 1. Tritiated water was found to rapidly equilibrate with the body water of chicks after injection. 2. 2. The 3H also rapidly appeared in both liver and carcass fatty acids, with the greatest rates of incorporation occurring in the initial time periods of measurement. 3. 3. Incorporation of 3H into fatty acids in the liver appeared to proceed primarily via de novo synthesis whereas incorporation of 3H into fatty acids in the carcass occurred primarily via chain elongation.

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Issue number3
StatePublished - 1976

Bibliographical note

Funding Information:
These studies (O'Hea & Leveille, 1968, 1969; Good-ridge & Ball, 1966, 1967) examined the rates of fatty acid synthesis in liver and adipose tissue. However, Yeh & Leveille (1972) found significant incorporation of \[1-14C\]acetate into fatty acids in the carcasses of chicks (the carcass represented the hepatectomized animal). Because 15 min elapsed between tracer injection and removal of the liver, the possibility of transfer of newly synthesized labelled fatty acids from the liver to the carcass could not be ruled out. Another possibility explaining the high rate of \[1-14C\]acetate incorporation into fatty acids in chick * Supported in part by Public Health Service Grants HL 14677 and GMO 1818. D.R.R. is the recipient of Career Development Award K04 AM 00112. Michigan Agriculture Experiment Station Journal Article No. 7341.


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