TY - JOUR
T1 - In Vivo Electrical Conductivity Contrast Imaging in a Mouse Model of Cancer Using High-Frequency Magnetoacoustic Tomography With Magnetic Induction (hfMAT-MI)
AU - Yu, Kai
AU - Shao, Qi
AU - Ashkenazi, Shai
AU - Bischof, John C.
AU - He, Bin
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/10
Y1 - 2016/10
N2 - Cancerous tissues have electrical-conductivity signatures different from normal tissues, which contain potentially useful information for early detection. Despite recent advancements in electrical-conductivity imaging and its applications, imaging electrical conductivities with high spatial resolution remains a challenge for non-invasive diagnosis of early-stage cancer. Among the various electrical-conductivity imaging methods, magnetoacoustic tomography with magnetic induction (MAT-MI) is a promising technology for non-invasive detection of breast cancer. However, previous efforts to use MAT-MI for cancer imaging have suffered due to insufficient spatial resolution. In this work, we have developed a high-frequency MAT-MI (hfMAT-MI) system with a 2-D spatial resolution of 1 mm, a significant improvement over previous methods. Furthermore, we demonstrated the performance of this method using an in vivo cancer model in nude mice with human breast xenograft hindlimb tumors. hfMAT-MI was able to resolve not only the boundaries between cancerous and healthy tissues, but also the tumors' internal structures. Importantly, we were able to track a growing tumor using our hfMAT-MI method for the first time in an in vivo mouse model, demonstrating the promise of this magneto-acoustic imaging system for effective detection and diagnosis of early-stage breast cancer.
AB - Cancerous tissues have electrical-conductivity signatures different from normal tissues, which contain potentially useful information for early detection. Despite recent advancements in electrical-conductivity imaging and its applications, imaging electrical conductivities with high spatial resolution remains a challenge for non-invasive diagnosis of early-stage cancer. Among the various electrical-conductivity imaging methods, magnetoacoustic tomography with magnetic induction (MAT-MI) is a promising technology for non-invasive detection of breast cancer. However, previous efforts to use MAT-MI for cancer imaging have suffered due to insufficient spatial resolution. In this work, we have developed a high-frequency MAT-MI (hfMAT-MI) system with a 2-D spatial resolution of 1 mm, a significant improvement over previous methods. Furthermore, we demonstrated the performance of this method using an in vivo cancer model in nude mice with human breast xenograft hindlimb tumors. hfMAT-MI was able to resolve not only the boundaries between cancerous and healthy tissues, but also the tumors' internal structures. Importantly, we were able to track a growing tumor using our hfMAT-MI method for the first time in an in vivo mouse model, demonstrating the promise of this magneto-acoustic imaging system for effective detection and diagnosis of early-stage breast cancer.
KW - Bioimpedance
KW - MAT-MI
KW - cancer detection
KW - electrical conductivity imaging
KW - electrical impedance imaging
KW - magnetoacoustic tomography with magnetic induction
UR - http://www.scopus.com/inward/record.url?scp=84991436076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991436076&partnerID=8YFLogxK
U2 - 10.1109/TMI.2016.2560146
DO - 10.1109/TMI.2016.2560146
M3 - Article
C2 - 27834641
AN - SCOPUS:84991436076
SN - 0278-0062
VL - 35
SP - 2301
EP - 2311
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
IS - 10
M1 - 7462269
ER -