In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism

Adolf Pfefferbaum, Edith V. Sullivan, Maj Hedehus, Elfar Adalsteinsson, Kelvin O. Lim, Michael Moseley

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

Background: Postmortem studies report degradation of brain white matter microstructure in chronic alcoholism, but until recently, in vivo neuroimaging could provide measurement only at a macrostructural level. The development of magnetic resonance diffusion tensor imaging (DTI) for clinical use offers a method for depicting and quantifying the diffusion properties of white matter expressed as intravoxel and intervoxel coherence of tracts and fibers. Methods: This study used DTI to examine the intravoxel coherence measured as fractional anisotropy (FA) and intervoxel coherence (C) of white matter tracts of the genu and splenium of the corpus callosum and of the centrum semiovale in 15 detoxified alcoholic men and 31 nonalcoholic control subjects. Exploratory correlational analyses examined the relationships between regional DTI measures and tests of attention and working memory in the alcoholic patients. Results: The alcoholic group had lower regional FA than the control group. C was lower in the alcoholics than controls in the splenium only. Working memory correlated positively with splenium FA, whereas attention correlated positively with genu C. Conclusions: These results provide in vivo evidence for disruption of white matter microstructure in alcoholism and suggest that interruption of white matter fiber coherence contributes to disturbance in attention and working memory in chronic alcoholism.

Original languageEnglish (US)
Pages (from-to)1214-1221
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume24
Issue number8
DOIs
StatePublished - Jan 1 2000

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Diffusion tensor imaging
Alcoholism
Diffusion Tensor Imaging
Anisotropy
Alcoholics
Short-Term Memory
Data storage equipment
Neuroimaging
Microstructure
Fibers
Magnetic resonance
Corpus Callosum
Brain
Degradation
Magnetic Resonance Spectroscopy
White Matter
Control Groups

Keywords

  • Alcohol
  • Coherence
  • Diffusion Imaging
  • Fractional Anisotropy
  • White Matter

Cite this

In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism. / Pfefferbaum, Adolf; Sullivan, Edith V.; Hedehus, Maj; Adalsteinsson, Elfar; Lim, Kelvin O.; Moseley, Michael.

In: Alcoholism: Clinical and Experimental Research, Vol. 24, No. 8, 01.01.2000, p. 1214-1221.

Research output: Contribution to journalArticle

Pfefferbaum, Adolf ; Sullivan, Edith V. ; Hedehus, Maj ; Adalsteinsson, Elfar ; Lim, Kelvin O. ; Moseley, Michael. / In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism. In: Alcoholism: Clinical and Experimental Research. 2000 ; Vol. 24, No. 8. pp. 1214-1221.
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