In vivo cell death mediated by synthetic ion channels

Bryan A. Smith, Megan M. Daschbach, Seth T. Gammon, Shuzhang Xiao, Sarah E. Chapman, Caroline Hudson, Mark Suckow, David Piwnica-Worms, George W. Gokel, W. Matthew Leevy

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

Original languageEnglish (US)
Pages (from-to)7977-7979
Number of pages3
JournalChemical Communications
Volume47
Issue number28
DOIs
StatePublished - Jul 28 2011

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    Smith, B. A., Daschbach, M. M., Gammon, S. T., Xiao, S., Chapman, S. E., Hudson, C., Suckow, M., Piwnica-Worms, D., Gokel, G. W., & Leevy, W. M. (2011). In vivo cell death mediated by synthetic ion channels. Chemical Communications, 47(28), 7977-7979. https://doi.org/10.1039/c1cc12933c