Abstract
Monoclonal antibodies specific for defined peptide-MHC complexes are now being used to physically detect T-cell receptor ligands. These reagents have resulted in the identification of the cells that present antigen in lymphoid and non-lymphoid tissues after various forms of antigen administration. In addition, recent advances in real-time imaging technology have begun to measure the rate and directionality of T-cell movement relative to antigen-presenting cells in lymph nodes, shedding light on the earliest events in T-cell activation in a physiological setting.
Original language | English (US) |
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Pages (from-to) | 120-125 |
Number of pages | 6 |
Journal | Current Opinion in Immunology |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2004 |