In vivo 7T MRI of the non-human primate brainstem

Laura M. Zitella, Yi Zi Xiao, Benjamin A. Teplitzky, Daniel J. Kastl, Yuval Duchin, Kenneth B. Baker, Jerrold L. Vitek, Gregor Adriany, Essa Yacoub, Noam Harel, Matthew D. Johnson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Structural brain imaging provides a critical framework for performing stereotactic and intraoperative MRI-guided surgical procedures, with procedural efficacy often dependent upon visualization of the target with which to operate. Here, we describe tools for in vivo, subject-specific visualization and demarcation of regions within the brainstem. High-field 7T susceptibility-weighted imaging and diffusion-weighted imaging of the brain were collected using a customized head coil from eight rhesus macaques. Fiber tracts including the superior cerebellar peduncle, medial lemniscus, and lateral lemniscus were identified using high-resolution probabilistic diffusion tractography, which resulted in three-dimensional fiber tract reconstructions that were comparable to those extracted from sequential application of a two-dimensional nonlinear brain atlas warping algorithm. In the susceptibility-weighted imaging, white matter tracts within the brainstem were also identified as hypointense regions, and the degree of hypointensity was age-dependent. This combination of imaging modalities also enabled identifying the location and extent of several brainstem nuclei, including the periaqueductal gray, pedunculopontine nucleus, and inferior colliculus. These clinically-relevant high-field imaging approaches have potential to enable more accurate and comprehensive subject-specific visualization of the brainstem and to ultimately improve patient-specific neurosurgical targeting procedures, including deep brain stimulation lead implantation.

Original languageEnglish (US)
Article numbere0127049
JournalPloS one
Volume10
Issue number5
DOIs
StatePublished - May 12 2015

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brain stem
Magnetic resonance imaging
Primates
Brain Stem
image analysis
Imaging techniques
Brain
Neuroimaging
brain
Visualization
Neurosurgical Procedures
Inferior Colliculi
Periaqueductal Gray
Diffusion Tensor Imaging
Deep Brain Stimulation
Atlases
Macaca mulatta
Fibers
Head
peduncle

Cite this

Zitella, L. M., Xiao, Y. Z., Teplitzky, B. A., Kastl, D. J., Duchin, Y., Baker, K. B., ... Johnson, M. D. (2015). In vivo 7T MRI of the non-human primate brainstem. PloS one, 10(5), [e0127049]. https://doi.org/10.1371/journal.pone.0127049

In vivo 7T MRI of the non-human primate brainstem. / Zitella, Laura M.; Xiao, Yi Zi; Teplitzky, Benjamin A.; Kastl, Daniel J.; Duchin, Yuval; Baker, Kenneth B.; Vitek, Jerrold L.; Adriany, Gregor; Yacoub, Essa; Harel, Noam; Johnson, Matthew D.

In: PloS one, Vol. 10, No. 5, e0127049, 12.05.2015.

Research output: Contribution to journalArticle

Zitella, LM, Xiao, YZ, Teplitzky, BA, Kastl, DJ, Duchin, Y, Baker, KB, Vitek, JL, Adriany, G, Yacoub, E, Harel, N & Johnson, MD 2015, 'In vivo 7T MRI of the non-human primate brainstem', PloS one, vol. 10, no. 5, e0127049. https://doi.org/10.1371/journal.pone.0127049
Zitella LM, Xiao YZ, Teplitzky BA, Kastl DJ, Duchin Y, Baker KB et al. In vivo 7T MRI of the non-human primate brainstem. PloS one. 2015 May 12;10(5). e0127049. https://doi.org/10.1371/journal.pone.0127049
Zitella, Laura M. ; Xiao, Yi Zi ; Teplitzky, Benjamin A. ; Kastl, Daniel J. ; Duchin, Yuval ; Baker, Kenneth B. ; Vitek, Jerrold L. ; Adriany, Gregor ; Yacoub, Essa ; Harel, Noam ; Johnson, Matthew D. / In vivo 7T MRI of the non-human primate brainstem. In: PloS one. 2015 ; Vol. 10, No. 5.
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