In vitro models of angiogenesis and vasculogenesis in fibrin gel

Kristen T. Morin, Robert T. Tranquillo

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

In vitro models of endothelial assembly into microvessels are useful for the study of angiogenesis and vasculogenesis. In addition, such models may be used to provide the microvasculature required to sustain engineered tissues. A large range of in vitro models of both angiogenesis and vasculogenesis have utilized fibrin gel as a scaffold. Although fibrin gel is conducive to endothelial assembly, its ultrastructure varies substantially based on the gel formulation and gelation conditions, making it challenging to compare between models. This work reviews existing models of endothelial assembly in fibrin gel and posits that differerences between models are partially caused by microstructural differences in fibrin gel.

Original languageEnglish (US)
Pages (from-to)2409-2417
Number of pages9
JournalExperimental Cell Research
Volume319
Issue number16
DOIs
StatePublished - Oct 1 2013

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Fibrin
Gels
Microvessels
In Vitro Techniques

Keywords

  • Angiogenesis
  • Fibrin
  • Vasculogenesis

Cite this

In vitro models of angiogenesis and vasculogenesis in fibrin gel. / Morin, Kristen T.; Tranquillo, Robert T.

In: Experimental Cell Research, Vol. 319, No. 16, 01.10.2013, p. 2409-2417.

Research output: Contribution to journalReview article

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