In vitro hydroxycarbonate apatite mineralization of CaO-SiO2 sol-gel glasses with a three-dimensionally ordered macroporous structure

H. Yan; K. Zhang; C. F. Blanford; L. F. Francis; A. Stein

doi:10.1021/cm000895e

In vitro hydroxycarbonate apatite mineralization of CaO-SiO₂ sol-gel glasses with a three-dimensionally ordered macroporous structure

H. Yan, K. Zhang, C. F. Blanford, L. F. Francis, A. Stein

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Abstract

A three-dimensionally ordered macroporous (3DOM) bioactive glass with acomposition of 80 mol % SiO₂ and 20 mol % CaO was synthesized by the sol-gel method using poly-(methyl methacrylate) (PMMA) colloidal crystal templates. A control sample with a matching composition was prepared by the same process but without PMMA templating. In vitro hydroxycarbonate apatite growth was investigated by soaking the bioactive glass in simulated body fluid (SBF) at body temperature (37°C) for varying lengths of time. The formation of a hydroxycarbonate apatite layer on the glass was studied by XRD, SEM, TEM, FTIR, and ICP techniques. The effects of the loading amount and the calcination temperature on the in vitro mineralization process were investigated. The 3DOM bioactive glass exhibited faster growth of apatite than the nontemplated control sample, probably because of its more accessible surface.

Original language	English (US)
Pages (from-to)	1374-1382
Number of pages	9
Journal	Chemistry of Materials
Volume	13
Issue number	4
DOIs	https://doi.org/10.1021/cm000895e
State	Published - 2001

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title = "In vitro hydroxycarbonate apatite mineralization of CaO-SiO2 sol-gel glasses with a three-dimensionally ordered macroporous structure",

abstract = "A three-dimensionally ordered macroporous (3DOM) bioactive glass with acomposition of 80 mol % SiO2 and 20 mol % CaO was synthesized by the sol-gel method using poly-(methyl methacrylate) (PMMA) colloidal crystal templates. A control sample with a matching composition was prepared by the same process but without PMMA templating. In vitro hydroxycarbonate apatite growth was investigated by soaking the bioactive glass in simulated body fluid (SBF) at body temperature (37°C) for varying lengths of time. The formation of a hydroxycarbonate apatite layer on the glass was studied by XRD, SEM, TEM, FTIR, and ICP techniques. The effects of the loading amount and the calcination temperature on the in vitro mineralization process were investigated. The 3DOM bioactive glass exhibited faster growth of apatite than the nontemplated control sample, probably because of its more accessible surface.",

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AU - Yan, H.

AU - Zhang, K.

AU - Blanford, C. F.

AU - Francis, L. F.

AU - Stein, A.

PY - 2001

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N2 - A three-dimensionally ordered macroporous (3DOM) bioactive glass with acomposition of 80 mol % SiO2 and 20 mol % CaO was synthesized by the sol-gel method using poly-(methyl methacrylate) (PMMA) colloidal crystal templates. A control sample with a matching composition was prepared by the same process but without PMMA templating. In vitro hydroxycarbonate apatite growth was investigated by soaking the bioactive glass in simulated body fluid (SBF) at body temperature (37°C) for varying lengths of time. The formation of a hydroxycarbonate apatite layer on the glass was studied by XRD, SEM, TEM, FTIR, and ICP techniques. The effects of the loading amount and the calcination temperature on the in vitro mineralization process were investigated. The 3DOM bioactive glass exhibited faster growth of apatite than the nontemplated control sample, probably because of its more accessible surface.

AB - A three-dimensionally ordered macroporous (3DOM) bioactive glass with acomposition of 80 mol % SiO2 and 20 mol % CaO was synthesized by the sol-gel method using poly-(methyl methacrylate) (PMMA) colloidal crystal templates. A control sample with a matching composition was prepared by the same process but without PMMA templating. In vitro hydroxycarbonate apatite growth was investigated by soaking the bioactive glass in simulated body fluid (SBF) at body temperature (37°C) for varying lengths of time. The formation of a hydroxycarbonate apatite layer on the glass was studied by XRD, SEM, TEM, FTIR, and ICP techniques. The effects of the loading amount and the calcination temperature on the in vitro mineralization process were investigated. The 3DOM bioactive glass exhibited faster growth of apatite than the nontemplated control sample, probably because of its more accessible surface.

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In vitro hydroxycarbonate apatite mineralization of CaO-SiO₂ sol-gel glasses with a three-dimensionally ordered macroporous structure

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