In vitro evaluation of a device for intra-pulmonary aerosol generation and delivery

Zeeshan H Syedain, Amir A. Naqwi, Myrna Dolovich, Arif Somani

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

For infants born with respiratory distress syndrome (RDS), liquid bolus delivery of surfactant administered through an endotracheal tube is common practice. While this method is generally effective, complications such as transient hypoxia, hypercapnia, and altered cerebral blood flow may occur. Aerosolized surfactant therapy has been explored as an alternative. Unfortunately, past efforts have led to disappointing results as aerosols were generated outside the lungs with significant pharyngeal deposition and minimal intrapulmonary instillation. A novel aerosol generator (Microjet™) is evaluated herein for intrapulmonary aerosol generation within an endotracheal tube and tested with Curosurf and Infasurf surfactants. Compared with other aerosol delivery devices, this process utilizes low air flow (range 0.01-0.2 L min-1) that is ideal for limiting potential barotrauma to the premature newborn lung. The mass mean diameter (MMD) of the particles for both tested surfactants was less than 4 μm, which is ideal for both uniform and distal lung delivery. As an indicator of phospholipid function, surfactant surface tension was measured before and after aerosol formation-with no significant difference. Moreover, this device has an outside diameter of <1 mm, which permits insertion into an endotracheal tube (of even 2.0 mm). In the premature infant where intravenous access is either technically challenging or difficult, aerosol drug delivery may provide an alternative route in patient resuscitation, stabilization, and care. Other potential applications of this type of device include the delivery of nutrients, antibiotics, and analgesics via the pulmonary route.

Original languageEnglish (US)
Pages (from-to)747-752
Number of pages6
JournalAerosol Science and Technology
Volume49
Issue number9
DOIs
StatePublished - Jan 1 2015

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Aerosols
surfactant
Surface-Active Agents
aerosol
Surface active agents
aerosol formation
Resuscitation
surface tension
hypoxia
phospholipid
antibiotics
low flow
Phospholipids
airflow
Antibiotics
Drug delivery
stabilization
drug
Nutrients
blood

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In vitro evaluation of a device for intra-pulmonary aerosol generation and delivery. / Syedain, Zeeshan H; Naqwi, Amir A.; Dolovich, Myrna; Somani, Arif.

In: Aerosol Science and Technology, Vol. 49, No. 9, 01.01.2015, p. 747-752.

Research output: Contribution to journalArticle

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