In vitro depression of the mitogenic response of lymphocytes from turkeys infected with hemorrhagic enteritis virus.

K. V. Nagaraja, B. L. Patel, D. A. Emery, B. S. Pomeroy, J. A. Newman

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A depression in the mitogenic response of lymphocytes was demonstrated in turkeys inoculated with hemorrhagic enteritis virus. Blood samples were collected (in heparin) once a week, beginning 1 week after the turkeys were inoculated. The whole blood assay was used to study lymphoblastogenesis. Concanavalin-A and phytohemagglutinin were the mitogens used: the radioisotope used was (125I)deoxyuridine (125IudR; 125I, sp act 5 Ci/mg). Suppression in the lymphocyte response in vitro was seen up to 5 weeks after the inoculations were done, after which there was a gradual recovery from suppression in the lymphocyte blastogenesis.

Original languageEnglish (US)
Pages (from-to)134-136
Number of pages3
JournalAmerican journal of veterinary research
Volume43
Issue number1
StatePublished - Jan 1 1982

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