In vitro antioxidant activity of dibenz[b,f]azepine and its analogues

H. Vijay Kumar, C. R. Gnanendra, Nagaraja Naik, D. Channe Gowda

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Dibenz[b,f]azepine and its five derivatives bearing different functional groups were synthesized by known methods. The compounds thus synthesized were evaluated for antioxidant potential through different in vitro models such as (DPPH) free radical scavenging activity, β-carotene-linoleic acid model system, reducing power assay and phosphomolybdenum method. Under our experimental condition among the synthesized compounds dibenz[b,f]azepine (a) and 10- methoxy-5H-dibenz[b,f]azepine (d) exhibited potent antioxidant activity in concentration dependent manner in all the above four methods. Butylated hydroxyl anisole (BHA) and ascorbic acid (AA) were used as the reference antioxidant compounds. The most active compounds like dibenz[b,f]azepine and its methoxy group substituent have shown more promising antioxidant and radical scavengers compared to the standards like BHA and ascorbic acid. It is conceivable from the studies that the tricyclic amines, i.e. dibenz[b, f]azepine and some of its derivatives are effective in their antioxidant activity properties.

Original languageEnglish (US)
Pages (from-to)1123-1132
Number of pages10
JournalE-Journal of Chemistry
Issue numberSUPPL. 2
StatePublished - 2008


  • Antioxidant activity
  • Dibenz[b,f]azepine
  • Phosphomolybdenum
  • Radical scavenging activity
  • Reducing power
  • β-Carotene-linoleic acid


Dive into the research topics of 'In vitro antioxidant activity of dibenz[b,f]azepine and its analogues'. Together they form a unique fingerprint.

Cite this