In vitro and in vivo adhesion properties evaluation carbomer six kinds bioadhesive material

Zhuang Zhao; Shou Ying Du; Yang Lu; Zhen Wang; Jie Bai; Yi Wang Guo

doi:10.11669/cpj.2014.24.010

In vitro and in vivo adhesion properties evaluation carbomer six kinds bioadhesive material

Zhuang Zhao, Shou Ying Du, Yang Lu, Zhen Wang, Jie Bai, Yi Wang Guo

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

OBJECTIVE: To comprehensively evaluate bioadhesive properties these materials by testing adhesion properties in vitro and in vivo. METHODS: Mucin from porcine stomach model, homemade adhesion measuring device and intestinal propulsion were used for in vitro and in vivo evaluation adhesive materials. RESULTS: Carbomer 934P and HPMC_K100M with high viscosity had optimal adhesion in their class, besides chitosan can be specifically bound by mucin from porcine stomach and it performed better than other materials in vivo adhesion. CONCLUSION: Above researches indicate that the bioadhesive properties had a positive correlation with viscosity in the same type material, and the relative molecular mass the materials, moisture absorption capacity, specific binding mucin and other factors should be considered in different types materials in the comprehensive evaluation.

Original language	English (US)
Pages (from-to)	2188-2192
Number of pages	5
Journal	Chinese Pharmaceutical Journal
Volume	49
Issue number	24
DOIs	https://doi.org/10.11669/cpj.2014.24.010
State	Published - Dec 22 2014
Externally published	Yes

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Publisher Copyright:
Copyright 2014 by the Chinese Pharmaceutical Association.

Keywords

Bioadhesion
Carbomer
Chitosan
Intestinal adhesion
Intestinal propulsion
Porcine stomach mucin

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10.11669/cpj.2014.24.010

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title = "In vitro and in vivo adhesion properties evaluation carbomer six kinds bioadhesive material",

abstract = "OBJECTIVE: To comprehensively evaluate bioadhesive properties these materials by testing adhesion properties in vitro and in vivo. METHODS: Mucin from porcine stomach model, homemade adhesion measuring device and intestinal propulsion were used for in vitro and in vivo evaluation adhesive materials. RESULTS: Carbomer 934P and HPMCK100M with high viscosity had optimal adhesion in their class, besides chitosan can be specifically bound by mucin from porcine stomach and it performed better than other materials in vivo adhesion. CONCLUSION: Above researches indicate that the bioadhesive properties had a positive correlation with viscosity in the same type material, and the relative molecular mass the materials, moisture absorption capacity, specific binding mucin and other factors should be considered in different types materials in the comprehensive evaluation.",

keywords = "Bioadhesion, Carbomer, Chitosan, Intestinal adhesion, Intestinal propulsion, Porcine stomach mucin",

author = "Zhuang Zhao and Du, {Shou Ying} and Yang Lu and Zhen Wang and Jie Bai and Guo, {Yi Wang}",

year = "2014",

month = dec,

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doi = "10.11669/cpj.2014.24.010",

language = "English (US)",

volume = "49",

pages = "2188--2192",

journal = "Chinese Pharmaceutical Journal",

issn = "1001-2494",

publisher = "Chinese Pharmaceutical Association",

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TY - JOUR

T1 - In vitro and in vivo adhesion properties evaluation carbomer six kinds bioadhesive material

AU - Zhao, Zhuang

AU - Du, Shou Ying

AU - Lu, Yang

AU - Wang, Zhen

AU - Bai, Jie

AU - Guo, Yi Wang

PY - 2014/12/22

Y1 - 2014/12/22

N2 - OBJECTIVE: To comprehensively evaluate bioadhesive properties these materials by testing adhesion properties in vitro and in vivo. METHODS: Mucin from porcine stomach model, homemade adhesion measuring device and intestinal propulsion were used for in vitro and in vivo evaluation adhesive materials. RESULTS: Carbomer 934P and HPMCK100M with high viscosity had optimal adhesion in their class, besides chitosan can be specifically bound by mucin from porcine stomach and it performed better than other materials in vivo adhesion. CONCLUSION: Above researches indicate that the bioadhesive properties had a positive correlation with viscosity in the same type material, and the relative molecular mass the materials, moisture absorption capacity, specific binding mucin and other factors should be considered in different types materials in the comprehensive evaluation.

AB - OBJECTIVE: To comprehensively evaluate bioadhesive properties these materials by testing adhesion properties in vitro and in vivo. METHODS: Mucin from porcine stomach model, homemade adhesion measuring device and intestinal propulsion were used for in vitro and in vivo evaluation adhesive materials. RESULTS: Carbomer 934P and HPMCK100M with high viscosity had optimal adhesion in their class, besides chitosan can be specifically bound by mucin from porcine stomach and it performed better than other materials in vivo adhesion. CONCLUSION: Above researches indicate that the bioadhesive properties had a positive correlation with viscosity in the same type material, and the relative molecular mass the materials, moisture absorption capacity, specific binding mucin and other factors should be considered in different types materials in the comprehensive evaluation.

KW - Bioadhesion

KW - Carbomer

KW - Chitosan

KW - Intestinal adhesion

KW - Intestinal propulsion

KW - Porcine stomach mucin

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JO - Chinese Pharmaceutical Journal

JF - Chinese Pharmaceutical Journal

IS - 24

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In vitro and in vivo adhesion properties evaluation carbomer six kinds bioadhesive material

Abstract

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