In vitro activity of the aminoglycoside antibiotic arbekacin against Acinetobacter baumannii-calcoaceticus isolated from war-wounded patients at Walter Reed Army Medical Center

Michael J. Zapor, Melissa Barber, Amy Summers, George H. Miller, Lee Ann Feeney, Lynn E. Eberly, Glenn Wortmann

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We determined the in vitro MIC of arbekacin against 200 Acinetobacter isolates recovered from wounded soldiers. The median MIC was 2 μg/ml (range, 0.5 to >64 μg/ml). A total of 97.5% of the isolates had arbekacin MICs of <8 μg/ml and 86.5% had MICs of ≤4 μg/ml. There was no association between the arbekacin MIC and susceptibility to 16 other antibiotics or the specimen source (P = 0.7239). Synergy testing suggested an enhanced effect of arbekacin-carbapenem combinations.

Original languageEnglish (US)
Pages (from-to)3015-3017
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume54
Issue number7
DOIs
StatePublished - Jul 2010

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