In situ formation of peracetic acid in iron-catalyzed epoxidations by hydrogen peroxide in the presence of acetic acid

Megumi Fujita, Larry Que

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Iron complexes (tpa)Fe( OTf)2 (1) and (bpmen)Fe(OTf)2 (2) [tpa = tris-(2-pyridylmethyl)-amine; bpmen = N,N′-bis-(2- pyridylmethyl)-N,N′-dimethyl-1,2-ethylenediamine] were found to catalyze the in situ formation of AcOOH from H2O2 and AcOH in the course of olefin oxidations. While oxidation of cyclooctene by H 2O2 catalyzed by 1 gives nearly equimolar epoxide and cis-diol products, introduction of AcOH to the reaction greatly enhances the selectivity for epoxidation. The resulting product distribution is nearly identical to that of cyclooctene oxidation by AcOOH catalyzed by 1. The in situ generation of AcOOH from H2O2 and AcOH in epoxidation catalyzed by some iron complexes opens a possibility to attain AcOOH-type efficiency of epoxidation using H2O2 as a terminal oxidant.

Original languageEnglish (US)
Pages (from-to)190-194
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume346
Issue number2-3
StatePublished - Feb 1 2004

Keywords

  • Dihydroxylation
  • Epoxidation
  • Hydrogen peroxide
  • Iron
  • N ligands
  • Peracetic acid

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