In a Pinch: Cefiderocol for CRAB Infections

Sara M. Karaba; Elizabeth B. Hirsch; Emily L. Heil

doi:10.1128/aac.00065-22

In a Pinch: Cefiderocol for CRAB Infections

Sara M. Karaba, Elizabeth B. Hirsch, Emily L. Heil

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Carbapenem-resistant Acinetobacter baumannii (CRAB) can cause significant infections with limited treatment options available. Falcone et al. (https://doi.org/ 10.1128/aac.02142-21) describe a single-center retrospective study comparing clinical outcomes among patients with CRAB infections treated with cefiderocol-containing versus colistin-containing regimens. Patients who received cefiderocol-containing regimens had lower 30-day mortality, though there are several limitations raised here, which make interpretation and applicability difficult.

Original language	English (US)
Journal	Antimicrobial agents and chemotherapy
Volume	66
Issue number	5
DOIs	https://doi.org/10.1128/aac.00065-22
State	Published - May 2022

Bibliographical note

Funding Information:
Copyright © 2022 American Society for Microbiology. All Rights Reserved. Address correspondence to Sara M. Karaba, sara.karaba@jhmi.edu. For the article discussed, see https://doi.org/ 10.1128/AAC.02142-21. The authors declare a conflict of interest. E.B.H. has received research funding from Merck and advisory board honoraria from Melinta, MeMed, and Merck. E.L.H. consults for Wolters/ Kluwer (LexiComp). The views expressed in this article do not necessarily reflect the views of the journal or of ASM. Published 11 April 2022

Publisher Copyright:
© 2022 American Society for Microbiology.

Keywords

Acinetobacter
CRAB
cefiderocol

PubMed: MeSH publication types

Journal Article
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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/aac.00065-22

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title = "In a Pinch: Cefiderocol for CRAB Infections",

abstract = "Carbapenem-resistant Acinetobacter baumannii (CRAB) can cause significant infections with limited treatment options available. Falcone et al. (https://doi.org/ 10.1128/aac.02142-21) describe a single-center retrospective study comparing clinical outcomes among patients with CRAB infections treated with cefiderocol-containing versus colistin-containing regimens. Patients who received cefiderocol-containing regimens had lower 30-day mortality, though there are several limitations raised here, which make interpretation and applicability difficult.",

keywords = "Acinetobacter, CRAB, cefiderocol",

author = "Karaba, {Sara M.} and Hirsch, {Elizabeth B.} and Heil, {Emily L.}",

note = "Funding Information: Copyright {\textcopyright} 2022 American Society for Microbiology. All Rights Reserved. Address correspondence to Sara M. Karaba, sara.karaba@jhmi.edu. For the article discussed, see https://doi.org/ 10.1128/AAC.02142-21. The authors declare a conflict of interest. E.B.H. has received research funding from Merck and advisory board honoraria from Melinta, MeMed, and Merck. E.L.H. consults for Wolters/ Kluwer (LexiComp). The views expressed in this article do not necessarily reflect the views of the journal or of ASM. Published 11 April 2022 Publisher Copyright: {\textcopyright} 2022 American Society for Microbiology.",

year = "2022",

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doi = "10.1128/aac.00065-22",

language = "English (US)",

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T2 - Cefiderocol for CRAB Infections

AU - Karaba, Sara M.

AU - Hirsch, Elizabeth B.

AU - Heil, Emily L.

N1 - Funding Information: Copyright © 2022 American Society for Microbiology. All Rights Reserved. Address correspondence to Sara M. Karaba, sara.karaba@jhmi.edu. For the article discussed, see https://doi.org/ 10.1128/AAC.02142-21. The authors declare a conflict of interest. E.B.H. has received research funding from Merck and advisory board honoraria from Melinta, MeMed, and Merck. E.L.H. consults for Wolters/ Kluwer (LexiComp). The views expressed in this article do not necessarily reflect the views of the journal or of ASM. Published 11 April 2022 Publisher Copyright: © 2022 American Society for Microbiology.

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AB - Carbapenem-resistant Acinetobacter baumannii (CRAB) can cause significant infections with limited treatment options available. Falcone et al. (https://doi.org/ 10.1128/aac.02142-21) describe a single-center retrospective study comparing clinical outcomes among patients with CRAB infections treated with cefiderocol-containing versus colistin-containing regimens. Patients who received cefiderocol-containing regimens had lower 30-day mortality, though there are several limitations raised here, which make interpretation and applicability difficult.

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In a Pinch: Cefiderocol for CRAB Infections

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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