Metronidazole (MTZ) is an antibacterial drug widely used for the treatment of protozoan and anaerobic infections in humans and animals. However, its low bioavailability necessitates the frequent administration of a high dose to attain an effective plasma concentration profile for therapy. To reduce the dose of MTZ, we have prepared a new cocrystal between MTZ and ethyl gallate (EG). The solid-state properties of MTZ-EG were characterized using complimentary techniques, including thermal, spectroscopic, microscopic, and X-ray crystallographic methods. The MTZ-EG cocrystal exhibits a higher solubility and faster dissolution than MTZ. The bioavailability of MTZ in rats was increased by 36% when MTZ-EG was used.
Bibliographical noteFunding Information:
Acknowledgments: We are grateful for the financial support of the Educational Commission of Hebei Province of China (ZD2019109) and Key R&D Program of Hebei Province (No. 19227505D).
Funding: This research was funded by Hebei Education Department, grant number “ZD2019109” Hebei Provincial Department of Science and Technology, grant number “19227505D” and National Natural Science Foundation of China, grant number “32002326”.
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- Ethyl gallate
PubMed: MeSH publication types
- Journal Article