TY - JOUR
T1 - Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2
AU - Kidd, Sharon A.
AU - Berry-Kravis, Elizabeth
AU - Choo, Tse Hwei
AU - Chen, Chen
AU - Esler, Amy
AU - Hoffmann, Anne
AU - Andrews, Howard F.
AU - Kaufmann, Walter E.
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a “triple criteria” diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS.
AB - We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a “triple criteria” diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS.
KW - Autism spectrum disorder
KW - Exploratory factor analysis
KW - Fragile X syndrome
KW - Receiver operating characteristic curves
KW - Social Communication Questionnaire
KW - Social Responsiveness Scale-2
UR - https://www.scopus.com/pages/publications/85069672979
UR - https://www.scopus.com/inward/citedby.url?scp=85069672979&partnerID=8YFLogxK
U2 - 10.1007/s10803-019-04148-0
DO - 10.1007/s10803-019-04148-0
M3 - Article
C2 - 31342442
AN - SCOPUS:85069672979
SN - 0162-3257
VL - 50
SP - 3276
EP - 3295
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 9
ER -