Abstract
We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a “triple criteria” diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS.
| Original language | English (US) |
|---|---|
| Journal | Journal of Autism and Developmental Disorders |
| DOIs | |
| State | Published - Jan 1 2019 |
Fingerprint
Keywords
- Autism spectrum disorder
- Exploratory factor analysis
- Fragile X syndrome
- Receiver operating characteristic curves
- Social Communication Questionnaire
- Social Responsiveness Scale-2
PubMed: MeSH publication types
- Journal Article
Cite this
Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2. / Kidd, Sharon A.; Berry-Kravis, Elizabeth; Choo, Tse Hwei; Chen, Chen; Esler, Amy N; Hoffmann, Anne; Andrews, Howard F.; Kaufmann, Walter E.
In: Journal of Autism and Developmental Disorders, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2
AU - Kidd, Sharon A.
AU - Berry-Kravis, Elizabeth
AU - Choo, Tse Hwei
AU - Chen, Chen
AU - Esler, Amy N
AU - Hoffmann, Anne
AU - Andrews, Howard F.
AU - Kaufmann, Walter E.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a “triple criteria” diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS.
AB - We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a “triple criteria” diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS.
KW - Autism spectrum disorder
KW - Exploratory factor analysis
KW - Fragile X syndrome
KW - Receiver operating characteristic curves
KW - Social Communication Questionnaire
KW - Social Responsiveness Scale-2
UR - http://www.scopus.com/inward/record.url?scp=85069672979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069672979&partnerID=8YFLogxK
U2 - 10.1007/s10803-019-04148-0
DO - 10.1007/s10803-019-04148-0
M3 - Article
C2 - 31342442
AN - SCOPUS:85069672979
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
ER -