Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2

Sharon A. Kidd, Elizabeth Berry-Kravis, Tse Hwei Choo, Chen Chen, Amy N Esler, Anne Hoffmann, Howard F. Andrews, Walter E. Kaufmann

Research output: Contribution to journalArticle

Abstract

We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a “triple criteria” diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS.

Original languageEnglish (US)
JournalJournal of Autism and Developmental Disorders
DOIs
StatePublished - Jan 1 2019

Fingerprint

Fragile X Syndrome
Communication
Psychometrics
Reproducibility of Results
ROC Curve
Statistical Factor Analysis
Autism Spectrum Disorder
Surveys and Questionnaires
Sensitivity and Specificity

Keywords

  • Autism spectrum disorder
  • Exploratory factor analysis
  • Fragile X syndrome
  • Receiver operating characteristic curves
  • Social Communication Questionnaire
  • Social Responsiveness Scale-2

PubMed: MeSH publication types

  • Journal Article

Cite this

Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2. / Kidd, Sharon A.; Berry-Kravis, Elizabeth; Choo, Tse Hwei; Chen, Chen; Esler, Amy N; Hoffmann, Anne; Andrews, Howard F.; Kaufmann, Walter E.

In: Journal of Autism and Developmental Disorders, 01.01.2019.

Research output: Contribution to journalArticle

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