Abstract
We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a “triple criteria” diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS.
Original language | English (US) |
---|---|
Pages (from-to) | 3276-3295 |
Number of pages | 20 |
Journal | Journal of Autism and Developmental Disorders |
Volume | 50 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2020 |
Bibliographical note
Publisher Copyright:© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords
- Autism spectrum disorder
- Exploratory factor analysis
- Fragile X syndrome
- Receiver operating characteristic curves
- Social Communication Questionnaire
- Social Responsiveness Scale-2