TY - JOUR
T1 - Improving solid-state properties of berberine chloride through forming a salt cocrystal with citric acid
AU - Lu, Qi
AU - Dun, Jiangnan
AU - Chen, Jia Mei
AU - Liu, Shuyu
AU - Sun, Changquan Calvin
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/1/10
Y1 - 2019/1/10
N2 - Berberine chloride (BCl) can exist as an anhydrate, monohydrate, dihydrate, and tetrahydrate. Therefore, it faces the problem of humidity dependent solid phase change when environmental humidity varies during manufacturing and storage of berberine tablets. We have discovered a new 1:1 cocrystal formed between berberine chloride and citric acid (BCl–CA) that exhibits better stability against variations in humidity while maintaining similar thermal stability, solubility, dissolution rate, and tabletability. Thus, BCl–CA is a good alternative crystal form for use in formulation to manufacture berberine tablets.
AB - Berberine chloride (BCl) can exist as an anhydrate, monohydrate, dihydrate, and tetrahydrate. Therefore, it faces the problem of humidity dependent solid phase change when environmental humidity varies during manufacturing and storage of berberine tablets. We have discovered a new 1:1 cocrystal formed between berberine chloride and citric acid (BCl–CA) that exhibits better stability against variations in humidity while maintaining similar thermal stability, solubility, dissolution rate, and tabletability. Thus, BCl–CA is a good alternative crystal form for use in formulation to manufacture berberine tablets.
KW - Berberine
KW - Citric acid
KW - Cocrystallization
KW - Stability
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U2 - 10.1016/j.ijpharm.2018.10.062
DO - 10.1016/j.ijpharm.2018.10.062
M3 - Article
C2 - 30385378
AN - SCOPUS:85055903483
SN - 0378-5173
VL - 554
SP - 14
EP - 20
JO - International journal of pharmaceutics
JF - International journal of pharmaceutics
ER -