Improving solid-state properties of berberine chloride through forming a salt cocrystal with citric acid

Qi Lu, Jiangnan Dun, Jia Mei Chen, Shuyu Liu, Calvin Sun

Research output: Contribution to journalArticle

Abstract

Berberine chloride (BCl) can exist as an anhydrate, monohydrate, dihydrate, and tetrahydrate. Therefore, it faces the problem of humidity dependent solid phase change when environmental humidity varies during manufacturing and storage of berberine tablets. We have discovered a new 1:1 cocrystal formed between berberine chloride and citric acid (BCl–CA) that exhibits better stability against variations in humidity while maintaining similar thermal stability, solubility, dissolution rate, and tabletability. Thus, BCl–CA is a good alternative crystal form for use in formulation to manufacture berberine tablets.

LanguageEnglish (US)
Pages14-20
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume554
DOIs
StatePublished - Jan 10 2019

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Berberine
Citric Acid
Chlorides
Salts
Humidity
Tablets
Solubility
Hot Temperature

Keywords

  • Berberine
  • Citric acid
  • Cocrystallization
  • Stability

Cite this

Improving solid-state properties of berberine chloride through forming a salt cocrystal with citric acid. / Lu, Qi; Dun, Jiangnan; Chen, Jia Mei; Liu, Shuyu; Sun, Calvin.

In: International Journal of Pharmaceutics, Vol. 554, 10.01.2019, p. 14-20.

Research output: Contribution to journalArticle

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