Improving QTL Mapping Resolution Based on Genotypic Sampling-a Case Using a RIL Population

Jian Bing YAN, Ji Hua TANG, Yi Jiang MENG, Xi Qing MA, Wen Tao TENG, Subhash Chander, Lin LI, Jian Sheng LI

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The QTL mapping results were compared with the genotypically selected and random samples of the same size on the base of a RIL population. The results demonstrated that there were no obvious differences in the trait distribution and marker segregation distortion between the genotypically selected and random samples with the same population size. However, a significant increase in QTL detection power, sensitivity, specificity, and QTL resolution in the genotypically selected samples were observed. Moreover, the highly significant effect was detected in small size of genotypically selected samples. In QTL mapping, phenotyping is a more sensitive limiting factor than genotyping so that the selection of samples could be an attractive strategy for increasing genome-wide QTL mapping resolution. The efficient selection of samples should be more helpful for QTL maker assistant selection, fine mapping, and QTL cloning.

Original languageEnglish (US)
Pages (from-to)617-624
Number of pages8
JournalActa Genetica Sinica
Volume33
Issue number7
DOIs
StatePublished - Jul 1 2006

Keywords

  • QTL mapping resolution
  • quantitative trait loci (QTL)
  • recombinant inbred lines (RIL)
  • selective mapping

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