Abstract
A batch of poorly flowing citric acid anhydrate was exposed to 69.9% relative humidity to prepare pure monohydrate with nearly identical particle size and morphology but different surface properties. Flow properties of the powders were tested using a ring shear cell. Results show the hydration can significantly improve flow properties of anhydrous citric acid.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1744-1749 |
| Number of pages | 6 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 98 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2009 |
Bibliographical note
Copyright:Copyright 2017 Elsevier B.V., All rights reserved.
Keywords
- Citric acid
- Hydrate
- Powder flow properties
- Shear cell
- Surface properties
- Unconfined yield strength