Improving powder flow properties of citric acid by crystal hydration

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36 Scopus citations

Abstract

A batch of poorly flowing citric acid anhydrate was exposed to 69.9% relative humidity to prepare pure monohydrate with nearly identical particle size and morphology but different surface properties. Flow properties of the powders were tested using a ring shear cell. Results show the hydration can significantly improve flow properties of anhydrous citric acid.

Original languageEnglish (US)
Pages (from-to)1744-1749
Number of pages6
JournalJournal of Pharmaceutical Sciences
Volume98
Issue number5
DOIs
StatePublished - May 2009

Keywords

  • Citric acid
  • Hydrate
  • Powder flow properties
  • Shear cell
  • Surface properties
  • Unconfined yield strength

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