Improving Mycoplasma hyopneumoniae diagnostic capabilities by harnessing the infection dynamics

Beatriz Garcia Morante, Dominiek Maes, Marina Sibila, Alyssa M Betlach, Amanda Sponheim, Albert Canturri, Maria Pieters

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Mycoplasma hyopneumoniae remains one of the most problematic bacterial pathogens for pig production. Despite an abundance of observational and laboratory testing capabilities for this organism, diagnostic interpretation of test results can be challenging and ambiguous. This is partly explained by the chronic nature of M. hyopneumoniae infection and its tropism for lower respiratory tract epithelium, which affects diagnostic sensitivities associated with sampling location and stage of infection. A thorough knowledge of the available tools for routine M. hyopneumoniae diagnostic testing, together with a detailed understanding of infection dynamics, are essential for optimizing sampling strategies and providing confidence in the diagnostic process. This study reviewed known information on sampling and diagnostic tools for M. hyopneumoniae and summarized literature reports of the dynamics of key infection outcomes, including clinical signs, lung lesions, pathogen detection, and humoral immune responses. The information gathethered in this manuscript can facilitate better understanding of the performance of different diagnostic approaches at various stages of infection with Mycoplasma hyopneumoniae.

Original languageEnglish (US)
Article number105877
JournalVeterinary Journal
Volume288
DOIs
StatePublished - Oct 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • Diagnostics
  • Infection dynamics
  • Lung lesions
  • Mycoplasma hyopneumoniae
  • PCR
  • Serology

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