Improving Alkyl-Alkyl Cross-Coupling Catalysis with Early Transition Metals through Mechanistic Understanding and Metal Tuning

Roman G. Belli, Victoria C. Tafuri, Courtney C. Roberts

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Alkyl-alkyl cross-coupling is a powerful C-C bond-forming transformation typically catalyzed by late transition metals. Herein, we report a mechanistic investigation into an early transition metal-catalyzed variant of this reaction. Through this mechanistic understanding, an ideal Y catalyst was determined through tuning of the metal in order to optimize the oxidation potential, which governs the rate-limiting step in this reaction. A wide substrate scope is revealed that includes a variety of functional groups as well as less activated substrates.

Original languageEnglish (US)
Pages (from-to)9430-9436
Number of pages7
JournalACS Catalysis
Volume12
Issue number15
DOIs
StatePublished - Aug 5 2022

Bibliographical note

Funding Information:
Financial support was provided by the University of Minnesota and the Petroleum Research Fund of the American Chemical Society (ACS PRF 62432-DNI1).

Publisher Copyright:
© 2022 American Chemical Society.

Keywords

  • alkyl-alkyl cross-coupling
  • metal tuning
  • transition metals

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