Alkyl-alkyl cross-coupling is a powerful C-C bond-forming transformation typically catalyzed by late transition metals. Herein, we report a mechanistic investigation into an early transition metal-catalyzed variant of this reaction. Through this mechanistic understanding, an ideal Y catalyst was determined through tuning of the metal in order to optimize the oxidation potential, which governs the rate-limiting step in this reaction. A wide substrate scope is revealed that includes a variety of functional groups as well as less activated substrates.
Bibliographical noteFunding Information:
Financial support was provided by the University of Minnesota and the Petroleum Research Fund of the American Chemical Society (ACS PRF 62432-DNI1).
© 2022 American Chemical Society.
- alkyl-alkyl cross-coupling
- metal tuning
- transition metals