Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors

Keyphrases

• Pharmacological Properties 100%
• Thyroid Hormone Receptor 100%
• Coactivator Binding Inhibitors 100%
• Cardiotoxicity 50%
• Cytotoxicity 50%
• Amines 50%
• Alkyl 50%
• Mechanistic Insight 50%
• Aromatic Ring 50%
• Active Compounds 50%
• Reduced Cytotoxicity 50%
• Electron-withdrawing 50%
• Structure-activity Relationship 50%
• Inhibitory Potency 50%
• Coactivator 50%
• High Potency 50%
• Pharmacological Activities 50%
• Ion Channel Activity 50%
• Comprehensive Survey 50%
• Sulfonyl 50%
• Alkyl Side Chains 50%
• Narrow Therapeutic Index 50%
• β-amino Ketones 50%
• In Vivo Toxicology 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• Cytotoxicity 100%
• Cardiotoxicity 50%
• Structure Activity Relationship 50%
• Pharmacological Activity 50%
• Aminoketone 50%
• Sulfonyl 50%
• Ion Channel 50%
• Therapeutic Window 50%
• Thyroid Hormone Receptor 50%
• In Vivo Toxicology 50%