Improved Wound Remodeling Correlates with Modulated TGF-beta Expression in Skin Diabetic Wounds Following Combined Red and Infrared Photobiomodulation Treatments

Reza Fekrazad, Arash Sarrafzadeh, Katayoun A.M. Kalhori, Imran Khan, Praveen R. Arany, Alessio Giubellino

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Diabetic wounds are a major cause of morbidity among patients with poorly controlled blood glucose levels. Conventional empirical wound care strategies have shown limited efficacy, and there is an urgent need to develop novel therapeutic strategies. Photobiomodulation treatments have shown positive therapeutic effects in several cell culture and animal models. In this study, we examined wound healing in diabetic rats following treatments with two laser wavelengths, namely red (660 nm) and infrared (808 nm) individually and in combination as compared to routine wound dressings. Immunostaining for TGF-β expression was performed at various times postwounding. We noted that the combination of red and infrared laser treatments correlated with decreased TGF-β1 levels at late stages in healing. There was no statistical significance with any treatments at an earlier time point. This study emphasizes the role of appropriate laser treatment protocols in modulating wound healing and remodeling responses.

Original languageEnglish (US)
Pages (from-to)775-779
Number of pages5
JournalPhotochemistry and Photobiology
Volume94
Issue number4
DOIs
StatePublished - Jul 1 2018

Bibliographical note

Funding Information:
Acknowledgements—This work was supported by the Intramural Research Program of the National Institutes of Health and start-up funds from University at Buffalo. This study was also funded mainly by Laser Research Center in Medical Sciences, AJA University of Medical Sciences.

Publisher Copyright:
© 2018 The American Society of Photobiology

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

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