Improved survival of glioblastoma patients treated at academic and high-volume facilities: A hospital-based study from the National Cancer Database

Ping Zhu, Xianglin L. Du, Jay Jiguang Zhu, Yoshua Esquenazi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The present study was designed to explore the association between facility type (academic center [AC] vs non-AC), facility volume (high-volume facility [HVF] vs low-volume facility [LVF]), and outcomes of glioblastoma (GBM) treatment. Methods: Based on the National Cancer Database (NCDB), GBM patients were categorized by treatment facility type (non-AC vs AC) and volume [4 categories (G1-G4): < 5.0, 5.0-14.9, 15.0-24.9, and ≥ 25.0, cases/year]. HVF was defined based on the 90th percentile of annual GBM cases (≥ 15.0 cases/year). Outcomes include overall survival (OS), the receipt of surgery and adjuvant therapies, 30-day readmission/mortality, 90-day mortality, and prolonged length of inpatient hospital stay (LOS). Kaplan-Meier methods and accelerated failure time (AFT) models were applied for survival analysis, and multivariable logistic regression models were performed to compare differences in the receipt of treatment and related short-term outcomes by facility type and volume. Results: A total of 40,256 GBM patients diagnosed between 2004 and 2014 were included. Patients treated at an AC & HVF experienced the longest survival (median OS: 13.3, 11.8, 11.1, and 10.3 months; time ratio [TR]: 1.00 [Ref.], 0.96, 0.92, and 0.89; for AC & HVF, AC & LVF, non-AC & HVF, and non-AC & LVF, respectively), regardless of care transition/treatment referral. Tumor resection, radiotherapy, and chemotherapy were most frequently utilized in AC & HVF. Prolonged LOS, 30-day readmission, and 90-day mortality were decreased by 20%, 22%, and 16% (p ≥ 0.001), respectively, at AC & HVF. Conclusions: This study provides evidence of superior outcomes when GBM patients are treated at AC and HVF. Standardization of health care across facility type and/or volume and comprehensive neuro-oncological care should be a potential goal in the management of GBM patients.

Original languageEnglish (US)
Pages (from-to)491-502
Number of pages12
JournalJournal of neurosurgery
Volume132
Issue number2
DOIs
StatePublished - 2020
Externally publishedYes

Bibliographical note

Funding Information:
This project was supported in part by the Dr. Marnie Rose Foundation and the Vivian L. Smith Foundation.

Publisher Copyright:
© AANS 2020, except where prohibited by US copyright law.

Keywords

  • Glioblastoma
  • Hospital-based
  • National Cancer Database
  • Oncology
  • Overall survival
  • Volume-based

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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