Abstract
Large animal models are important tools for hepatocellular carcinoma (HCC) research, especially in studies of hepatic vasculature, interventional techniques, and radiofrequency or microwave hyperthermia. Currently, diethylnitrosamine (DENA)-induced HCC in pigs is the only large animal model for in situ HCC with a tumor latency of 10-26 months. While phenobarbital (PB) is often used to accelerate DENA-induced HCC in rodents, it has not been previously studied in the porcine model. Therefore, we hypothesize that the addition of PB in the DENA-induced HCC porcine model will accelerate tumor latency compared to DENA alone. HCC and benign lesions were seen on serial MRI and confirmed on histopathology. Liver and tumors were further characterized by CT angiography, vascular corrosion casting, and permittivity measurements.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 360-369 |
| Number of pages | 10 |
| Journal | Oncology (Switzerland) |
| Volume | 95 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1 2018 |
| Externally published | Yes |
Bibliographical note
Funding Information:J.C.H. acknowledges support from Baylor College of Medicine Oncology Scholars (T32CA174647). S.A.C. and S.J.C. acknowledge support from the Kanzius Cancer Research Foundation. We acknowledge and thank the BCM Core for Advanced MRI (CAM-RI), including Operations Director, Krista Runge, and MR technologist, Lacey DeLay for scanning assistance. We acknowledge and thank the BCM Center for Comparative Medicine, including Dalis Collins and the entire veterinary team.
Publisher Copyright:
© 2018 S. Karger AG, Basel.
Keywords
- Diethylnitrosamine
- Hepatocellular carcinoma
- Phenobarbital
- Porcine
