Improved selectivity of a high-performance liquid chromatography assay for debrisoquine and its 4-hydroxy metabolite from urine

Keyphrases

• High-performance Liquid Chromatography 100%
• Enhanced Selectivity 100%
• Hydroxy Metabolites 100%
• Debrisoquine 100%
• Human Subjects 33%
• Metabolism 33%
• Mobile Phase 33%
• Between-day 33%
• Acetonitrile 33%
• Hydroxylation 33%
• Antihypertensive Drugs 33%
• Coefficient of Variation 33%
• Within-day 33%
• High-performance Liquid Chromatography Method 33%
• Primary Metabolites 33%
• Healthy Male Volunteers 33%
• Urine Analysis 33%
• Extraction Column 33%
• Sodium Dihydrogen Orthophosphate 33%

Chemistry

• High-Pressure Liquid Chromatography 100%
• Metabolite 100%
• Liquid Chromatography 50%
• Flow Kinetics 50%
• Dihydrogen 50%
• Mobile Phase Composition 50%
• Sodium 50%
• Extraction Column 50%
• Acetonitrile 50%
• Urine Analysis 50%
• hydroxylation 50%
• Antihypertensive Agent 50%

Pharmacology, Toxicology and Pharmaceutical Science

• High Performance Liquid Chromatography 100%
• Debrisoquine 100%
• Phosphate 33%
• Human 33%
• Antihypertensive Agent 33%
• Acetonitrile 33%
• 4 Hydroxydebrisoquine 33%