Our ultimate goal is to predict adverse cardiovascular events from CT calcium score exams using radiomics. Unlike the traditional whole heart Agatston score, our approach analyzes individual calcifications, creating a challenge for accurate/reproducible assessments. Optional preprocessing consisted of 3D blind deconvolution optimized on masked sharp structures, giving PSFs similar to measured ones, followed by noise reduction. In our experiment, we found that blind deconvolution improves the accuracy and reproducibility of CT calcium score evaluation. It is beneficial to use this to predict adverse cardiovascular event since it provides a robust and accurate evaluation of clinically relevant and pre-clinical calcifications. We conclude that for archived images where PSFs are unavailable, 3D blind deconvolution is a useful preprocessing step for improved radiomics assessments of CT-calcium-score images.
|Original language||English (US)|
|Title of host publication||Medical Imaging 2021|
|Subtitle of host publication||Biomedical Applications in Molecular, Structural, and Functional Imaging|
|Editors||Barjor S. Gimi, Andrzej Krol|
|State||Published - 2021|
|Event||Medical Imaging 2021: Biomedical Applications in Molecular, Structural, and Functional Imaging - Virtual, Online, United States|
Duration: Feb 15 2021 → Feb 19 2021
|Name||Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|Conference||Medical Imaging 2021: Biomedical Applications in Molecular, Structural, and Functional Imaging|
|Period||2/15/21 → 2/19/21|
Bibliographical noteFunding Information:
The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201800003I, HHSN268201800004I, HHSN268201800005I, HHSN268201800006I, and HHSN-268201800007I from the National Heart, Lung, and Blood Institute (NHLBI). Collection of CT data was in part supported by RO1 HL098445 (to JJC). Hao Wu was supported by the Interdisciplinary Biomedical Imaging Training Program, NIH T32EB007509 administered by the Department of Biomedical Engineering, Case Western Reserve University. This report is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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- Calcium score
- Coronary artery calcification