Improved reproducibility of CT calcium score using blind deconvolution

Yingnan Song, Ammar Hoori, Hao Wu, Sadeer Al-Kindi, Jared Christian Durieux, James G. Terry, David R. Jacobs, Jamal S. Rana, John Jeffrey Carr, David L. Wilson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


Our ultimate goal is to predict adverse cardiovascular events from CT calcium score exams using radiomics. Unlike the traditional whole heart Agatston score, our approach analyzes individual calcifications, creating a challenge for accurate/reproducible assessments. Optional preprocessing consisted of 3D blind deconvolution optimized on masked sharp structures, giving PSFs similar to measured ones, followed by noise reduction. In our experiment, we found that blind deconvolution improves the accuracy and reproducibility of CT calcium score evaluation. It is beneficial to use this to predict adverse cardiovascular event since it provides a robust and accurate evaluation of clinically relevant and pre-clinical calcifications. We conclude that for archived images where PSFs are unavailable, 3D blind deconvolution is a useful preprocessing step for improved radiomics assessments of CT-calcium-score images.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2021
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor S. Gimi, Andrzej Krol
ISBN (Electronic)9781510640290
StatePublished - 2021
EventMedical Imaging 2021: Biomedical Applications in Molecular, Structural, and Functional Imaging - Virtual, Online, United States
Duration: Feb 15 2021Feb 19 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2021: Biomedical Applications in Molecular, Structural, and Functional Imaging
Country/TerritoryUnited States
CityVirtual, Online

Bibliographical note

Funding Information:
The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201800003I, HHSN268201800004I, HHSN268201800005I, HHSN268201800006I, and HHSN-268201800007I from the National Heart, Lung, and Blood Institute (NHLBI). Collection of CT data was in part supported by RO1 HL098445 (to JJC). Hao Wu was supported by the Interdisciplinary Biomedical Imaging Training Program, NIH T32EB007509 administered by the Department of Biomedical Engineering, Case Western Reserve University. This report is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.


  • Calcium score
  • Coronary artery calcification
  • Deconvolution


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