Improved Outcomes of Kidney Transplantation in Infants (Age < 2 years): A Single-Center Experience

Blanche M. Chavers, Michelle N. Rheault, Arthur J. Matas, Scott C. Jackson, Marie E. Cook, Thomas E. Nevins, John S. Najarian, Srinath Chinnakotla

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background Infants (age, < 2 years) with end-stage renal disease (ESRD) have increased morbidity and mortality. We evaluated our long-Term outcomes of kidney transplants (KTx) in infants. Methods Between 1984 and 2014, 136 infants underwent KTx. We examined trends in survival rates and complications by era (1984-1993 [era 1], 1994-2003 [era 2], 2004-2014 [era 3]). Results Patients were 92.6% white and 70.6% males. Posttransplant (Tx) initial length of hospital stay declined 37% over the 30-year period (P <0.01). Ten-year death-censored graft survival improved from 60% (era 1) to 80% (era 2) (P = 0.04). The incidence of acute rejection, graft thrombosis, cytomegalovirus, and urine leaks did not significantly change across eras. Frequency of Epstein-Barr virus diagnosis (era 2 vs era 3, P < 0.01) increased. Post-Tx lymphoproliferative disorder incidence was increased in era 2 compared with eras 1 and 3 (P = 0.03). Conclusions Infants deserve earlier consideration for KTx. Length of initial hospital stay and patient and graft survival rates after KTx have improved in infants since 1984.

Original languageEnglish (US)
Pages (from-to)284-290
Number of pages7
JournalTransplantation
Volume102
Issue number2
DOIs
StatePublished - Feb 1 2018

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