IMPROVED EARLY DIAGNOSIS OF ADULT POLYCYSTIC KIDNEY DISEASE WITH FLANKING DNA MARKERS

M. H. Breuning, H. Brunner, J. J. Saris, G. J.B. Van Ommen, S. T. Reeders, J. W. Ijdo, A. Verwest, P. L. Pearson

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

A new polymorphic DNA marker for the diagnosis of autosomal dominant adult polycystic kidney disease (APKD) has been identified. The new marker, 24-1, flanks the APKD gene on the side opposite to the alpha globin on the short arm of chromosome 16. When both DNA polymorphisms bracketing the gene are informative the reliability of prenatal and presymptom diagnosis of polycystic kidney disease in non-recombinants (92% of cases) is more than 99%.

Original languageEnglish (US)
Pages (from-to)1359-1361
Number of pages3
JournalThe Lancet
Volume330
Issue number8572
DOIs
StatePublished - Dec 12 1987
Externally publishedYes

Bibliographical note

Funding Information:
Dr M. Hofker, Dr J. den Dunnen, and Dr M. Wapenaar for preparing the vectors and for stimulating discussions; and the families for their cooperation. The studies were financed by the Netherlands Kidney Foundation.

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