Improved Chemical Syntheses of 1- and 5-Deazariboflavin

Erin E. Carlson; Laura L. Kiessling

doi:10.1021/jo049859f

Improved Chemical Syntheses of 1- and 5-Deazariboflavin

Erin E. Carlson, Laura L. Kiessling

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The cofactor flavin adenine dinucleotide (FAD) is required for the catalytic activity of a large class of enzymes known as flavoenzymes. Because flavin cofactors participate in catalysis via a number of different mechanisms, isoalloxazine analogues are valuable for mechanistic studies. We report improved chemical syntheses for the preparation of the two key analogues, 5-deazariboflavin and 1-deazariboflavin.

Original language	English (US)
Pages (from-to)	2614-2617
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	69
Issue number	7
DOIs	https://doi.org/10.1021/jo049859f
State	Published - Apr 2 2004

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abstract = "The cofactor flavin adenine dinucleotide (FAD) is required for the catalytic activity of a large class of enzymes known as flavoenzymes. Because flavin cofactors participate in catalysis via a number of different mechanisms, isoalloxazine analogues are valuable for mechanistic studies. We report improved chemical syntheses for the preparation of the two key analogues, 5-deazariboflavin and 1-deazariboflavin.",

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Improved Chemical Syntheses of 1- and 5-Deazariboflavin

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