Improved Chemical Syntheses of 1- and 5-Deazariboflavin

Erin E. Carlson, Laura L. Kiessling

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The cofactor flavin adenine dinucleotide (FAD) is required for the catalytic activity of a large class of enzymes known as flavoenzymes. Because flavin cofactors participate in catalysis via a number of different mechanisms, isoalloxazine analogues are valuable for mechanistic studies. We report improved chemical syntheses for the preparation of the two key analogues, 5-deazariboflavin and 1-deazariboflavin.

Original languageEnglish (US)
Pages (from-to)2614-2617
Number of pages4
JournalJournal of Organic Chemistry
Issue number7
StatePublished - Apr 2 2004


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