Abstract
The cofactor flavin adenine dinucleotide (FAD) is required for the catalytic activity of a large class of enzymes known as flavoenzymes. Because flavin cofactors participate in catalysis via a number of different mechanisms, isoalloxazine analogues are valuable for mechanistic studies. We report improved chemical syntheses for the preparation of the two key analogues, 5-deazariboflavin and 1-deazariboflavin.
Original language | English (US) |
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Pages (from-to) | 2614-2617 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 69 |
Issue number | 7 |
DOIs | |
State | Published - Apr 2 2004 |