Improved breast cancer survival among hormone replacement therapy users is durable after 5 years of additional follow-up

Dara Christante, Su Ellen Pommier, Jennifer Garreau, Patrick Muller, Brett LaFleur, Rodney Pommier

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: We previously reported that breast cancer patients who used hormone replacement therapy (HRT) had significantly lower stage tumors and higher survival than never-users. We present an update with longer follow-up, HRT use data, and in vitro research. Methods: Our database of 292 postmenopausal breast cancer patients was updated to include HRT type, duration, and disease status. In vitro effects of estrogen (E) and/or medroxyprogesterone (MPA) on breast cancer cell growth were measured. Results: Tumor prognostic factors were better and survival rates higher for both E and combination HRT users of any duration. Use greater than 10 years correlated with node-negative disease, mammographically detected tumors, and 100% survival. E supported minimal proliferation; MPA induced cell death; E+MPA results were similar to E alone. Conclusions: HRT users, regardless of type or duration of HRT use, continued to have higher survival rates. In vitro results supported the clinical finding that outcomes for users of E and E+MPA were similar.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalAmerican journal of surgery
Volume196
Issue number4
DOIs
StatePublished - Oct 1 2008

Keywords

  • Breast cancer
  • Hormone replacement therapy
  • Medroxyprogesterone

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