Improved biocompatibility of bovine pericardium using a new method of cross linking

Kangxiong Liao; Eli Seifter; Guangfu Gong; Edward L. Yellin; Robert W M Frater

Improved biocompatibility of bovine pericardium using a new method of cross linking

Kangxiong Liao, Eli Seifter, Guangfu Gong, Edward L. Yellin, Robert W M Frater

Surgery

Research output: Contribution to journal › Conference article › peer-review

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Abstract

The authors used glycerol (Gly) as a cross linking agent to treat bovine pericardium (BP) and compared it mechanically (tensile test) and biologically (subcutaneous implantation in rats) with glutaraldehyde (Glu) fixed lonescu-Shiley BP (ISBP). Maximum tensile stress (St_max) was the same in both groups (n = 12 each), while maximum strain (Sn_max) was larger in Gly BP. Calcium content (Ca) was lower and water content of tissue (WC) was higher in implants of Gly BP versus ISBP (n = 9 each). Gly BP appeared more hydrated than ISBP in specimens studied by scanning electron microscopy (SEM). In addition, SEM of three Gly BP mitral valves in sheep showed good growth of endothelial (En) cells. These biomechanical advantages of Gly BP over ISBP suggest that Gly may be a useful substitute for Glu in cross linking bovine pericardial valves.

Original language	English (US)
Pages (from-to)	M175-M176
Journal	ASAIO Transactions
Volume	37
Issue number	3
State	Published - Jul 1 1991

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@article{1424248af1c1475584df9d8087dab7e1,

title = "Improved biocompatibility of bovine pericardium using a new method of cross linking",

abstract = "The authors used glycerol (Gly) as a cross linking agent to treat bovine pericardium (BP) and compared it mechanically (tensile test) and biologically (subcutaneous implantation in rats) with glutaraldehyde (Glu) fixed lonescu-Shiley BP (ISBP). Maximum tensile stress (Stmax) was the same in both groups (n = 12 each), while maximum strain (Snmax) was larger in Gly BP. Calcium content (Ca) was lower and water content of tissue (WC) was higher in implants of Gly BP versus ISBP (n = 9 each). Gly BP appeared more hydrated than ISBP in specimens studied by scanning electron microscopy (SEM). In addition, SEM of three Gly BP mitral valves in sheep showed good growth of endothelial (En) cells. These biomechanical advantages of Gly BP over ISBP suggest that Gly may be a useful substitute for Glu in cross linking bovine pericardial valves.",

author = "Kangxiong Liao and Eli Seifter and Guangfu Gong and Yellin, {Edward L.} and Frater, {Robert W M}",

year = "1991",

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language = "English (US)",

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journal = "ASAIO Transactions",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Improved biocompatibility of bovine pericardium using a new method of cross linking

AU - Liao, Kangxiong

AU - Seifter, Eli

AU - Gong, Guangfu

AU - Yellin, Edward L.

AU - Frater, Robert W M

PY - 1991/7/1

Y1 - 1991/7/1

N2 - The authors used glycerol (Gly) as a cross linking agent to treat bovine pericardium (BP) and compared it mechanically (tensile test) and biologically (subcutaneous implantation in rats) with glutaraldehyde (Glu) fixed lonescu-Shiley BP (ISBP). Maximum tensile stress (Stmax) was the same in both groups (n = 12 each), while maximum strain (Snmax) was larger in Gly BP. Calcium content (Ca) was lower and water content of tissue (WC) was higher in implants of Gly BP versus ISBP (n = 9 each). Gly BP appeared more hydrated than ISBP in specimens studied by scanning electron microscopy (SEM). In addition, SEM of three Gly BP mitral valves in sheep showed good growth of endothelial (En) cells. These biomechanical advantages of Gly BP over ISBP suggest that Gly may be a useful substitute for Glu in cross linking bovine pericardial valves.

AB - The authors used glycerol (Gly) as a cross linking agent to treat bovine pericardium (BP) and compared it mechanically (tensile test) and biologically (subcutaneous implantation in rats) with glutaraldehyde (Glu) fixed lonescu-Shiley BP (ISBP). Maximum tensile stress (Stmax) was the same in both groups (n = 12 each), while maximum strain (Snmax) was larger in Gly BP. Calcium content (Ca) was lower and water content of tissue (WC) was higher in implants of Gly BP versus ISBP (n = 9 each). Gly BP appeared more hydrated than ISBP in specimens studied by scanning electron microscopy (SEM). In addition, SEM of three Gly BP mitral valves in sheep showed good growth of endothelial (En) cells. These biomechanical advantages of Gly BP over ISBP suggest that Gly may be a useful substitute for Glu in cross linking bovine pericardial valves.

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M3 - Conference article

C2 - 1751098

AN - SCOPUS:0026184497

SN - 0889-7190

VL - 37

SP - M175-M176

JO - ASAIO Transactions

JF - ASAIO Transactions

IS - 3

ER -

Improved biocompatibility of bovine pericardium using a new method of cross linking

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