An improved and practical route for a large-scale synthesis of 2-deoxy-L-ribose starting from L-arabinose has been developed. This is the first reported synthesis of 2-deoxy-L-ribose in which deoxygenation has been mediated by hypophosphite reagents instead of by organotin reagents.
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- N-ethylpiperidine hypophosphite
- hypophosphite-mediated deoxygenation
- hypophosphorous acid