TY - JOUR
T1 - Importance of oxygen functions in the biological hydroxylation of flavonoids by absidia blackesleeana
AU - Abul-Hajj, Y. J.
AU - Ghaffari, M. A.
AU - Mehrotra, S.
PY - 1991
Y1 - 1991
N2 - 1. The synthesis and microbiological transformation of 2-phenyl-1-tetralone (compound 3, 1-deoxyisoflavanone), 3-phenyl-l-tetralone (compound 4, 1-deoxyflavanone), 2-phenylchroman (compound 7, 4-deoxyflavanone), 3-phenylchroman (compound 8, 4-deoxyisoflavanone) and 1,2-dihydro-3-phenylnaphthalene (compound 10, 1,4-dideoxy-dehydroflavanone) by Absidia blackesleeana are described. 2. Compounds 3, 4, 7 and 8 were hydroxylated at the 4'position while compound 10 was not utilized as a substrate. The two phenylchroman analgoues 7 and 8 gave approximately the same yield (22% and 26% respectively) of the 4'hydroxylation products, while the phenyltetralone analogues 3 and 4 showed significant differences in 4'hydroxylation (2% and 47% respectively).
AB - 1. The synthesis and microbiological transformation of 2-phenyl-1-tetralone (compound 3, 1-deoxyisoflavanone), 3-phenyl-l-tetralone (compound 4, 1-deoxyflavanone), 2-phenylchroman (compound 7, 4-deoxyflavanone), 3-phenylchroman (compound 8, 4-deoxyisoflavanone) and 1,2-dihydro-3-phenylnaphthalene (compound 10, 1,4-dideoxy-dehydroflavanone) by Absidia blackesleeana are described. 2. Compounds 3, 4, 7 and 8 were hydroxylated at the 4'position while compound 10 was not utilized as a substrate. The two phenylchroman analgoues 7 and 8 gave approximately the same yield (22% and 26% respectively) of the 4'hydroxylation products, while the phenyltetralone analogues 3 and 4 showed significant differences in 4'hydroxylation (2% and 47% respectively).
UR - http://www.scopus.com/inward/record.url?scp=0025868319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025868319&partnerID=8YFLogxK
U2 - 10.3109/00498259109039557
DO - 10.3109/00498259109039557
M3 - Article
C2 - 1788985
AN - SCOPUS:0025868319
SN - 0049-8254
VL - 21
SP - 1171
EP - 1177
JO - Xenobiotica
JF - Xenobiotica
IS - 9
ER -