TY - JOUR
T1 - Implications of Atrial Fibrillation for Guideline-Directed Therapy in Patients With Heart Failure
T2 - JACC State-of-the-Art Review
AU - Newman, Joshua D.
AU - O'Meara, Eileen
AU - Böhm, Michael
AU - Savarese, Gianluigi
AU - Kelly, Patricia R.
AU - Vardeny, Orly
AU - Allen, Larry A.
AU - Lancellotti, Patrizio
AU - Gottlieb, Stephen S.
AU - Samad, Zainab
AU - Morris, Alanna A.
AU - Desai, Nihar R.
AU - Rosano, Giuseppe M.C.
AU - Teerlink, John R.
AU - Giraldo, Clara Saldarriaga
AU - Lindenfeld, Jo Ann
N1 - Publisher Copyright:
© 2024 American College of Cardiology Foundation
PY - 2024/3/5
Y1 - 2024/3/5
N2 - Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular conditions that frequently coexist. Among patients with HF, more than one-half also have AF. Both are associated with significant morbidity and mortality. Moreover, the prevalence of each is increasing globally, and this trend is expected to continue owing to an aging population and increased life expectancy. Diagnosis of AF in a patient with HF is associated with greater symptom burden, more frequent hospitalizations, and a worse prognosis. Guideline-directed medical therapy (GDMT) for HF can affect the incidence of AF. Once present, AF can influence the efficacy of some components of GDMT for HF. In this review, we discuss the effect of GDMT for HF across the spectrum of ejection fraction on prevention of AF as well as the benefit of GDMT in patients with vs without AF.
AB - Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular conditions that frequently coexist. Among patients with HF, more than one-half also have AF. Both are associated with significant morbidity and mortality. Moreover, the prevalence of each is increasing globally, and this trend is expected to continue owing to an aging population and increased life expectancy. Diagnosis of AF in a patient with HF is associated with greater symptom burden, more frequent hospitalizations, and a worse prognosis. Guideline-directed medical therapy (GDMT) for HF can affect the incidence of AF. Once present, AF can influence the efficacy of some components of GDMT for HF. In this review, we discuss the effect of GDMT for HF across the spectrum of ejection fraction on prevention of AF as well as the benefit of GDMT in patients with vs without AF.
KW - atrial fibrillation
KW - catheter ablation
KW - guideline-directed medical therapy
KW - heart failure
UR - http://www.scopus.com/inward/record.url?scp=85185493245&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85185493245&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2023.12.033
DO - 10.1016/j.jacc.2023.12.033
M3 - Review article
C2 - 38418008
AN - SCOPUS:85185493245
SN - 0735-1097
VL - 83
SP - 932
EP - 950
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 9
ER -
