Implementation Science for the Prevention and Treatment of HIV among Adolescents and Young Adults in Sub-Saharan Africa: A Scoping Review

Susan Vorkoper, Kadija M. Tahlil, Nadia A. Sam-Agudu, Joseph D. Tucker, Alicia A. Livinski, Frances Fernando, Rachel Sturke

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Despite many evidence-based adolescent and young adult (AYA) HIV interventions, few are implemented at scale in sub-Saharan Africa (SSA). A growing implementation science literature provides important context for scaling up AYA HIV interventions in this high HIV-burden region. This scoping review examined the use of implementation research in AYA HIV studies conducted in SSA. We searched five databases and included articles which focused on AYA (10–24 years old), addressed HIV prevention or treatment, were conducted exclusively in SSA countries, and included an implementation science outcome. We included 44 articles in 13 SSA countries. Most were in East (52.3%) and South Africa (27.3%), and half focused exclusively on HIV prevention components of the care continuum. Acceptability and feasibility were the most cited implementation science outcomes. Only four articles used an established implementation science framework. The findings informed our recommendations to guide the design, implementation, and dissemination of further studies and health policymaking.

Original languageEnglish (US)
Pages (from-to)7-23
Number of pages17
JournalAIDS and Behavior
StatePublished - May 2023
Externally publishedYes

Bibliographical note

Funding Information:
Funding declaration: NASA is funded by the NIH National Institute of Child Health and Human Development (NICHD) grant #R01HD089866 and by an NIH/FIC award through AHISA for the Central and West Africa Implementation Science Alliance (CAWISA). JDT and KMT are supported by NICHD grant #UH3HD096929.

Publisher Copyright:
© 2022, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.


  • Adolescent
  • HIV
  • Implementation science
  • Sub-saharan Africa
  • Young adult

PubMed: MeSH publication types

  • Review
  • Journal Article


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