Implementation of Cardovascular Cell Therapy Network trials: Challenges, innovation and lessons learned from experience in the CCTRN

Ki E. Park; Lemuel A. Moyé; Timothy D. Henry; Emerson C. Perin; Shelly L. Sayre; Judy Bettencourt; Rachel W. Vojvodic; Rachel E. Olson; Carl J. Pepine

doi:10.1586/14779072.2013.839943

Implementation of Cardovascular Cell Therapy Network trials: Challenges, innovation and lessons learned from experience in the CCTRN

Ki E. Park, Lemuel A. Moyé, Timothy D. Henry, Emerson C. Perin, Shelly L. Sayre, Judy Bettencourt, Rachel W. Vojvodic, Rachel E. Olson, Carl J. Pepine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The cardiovascular cell therapy network was developed by the National Heart, Lung and Blood Institute to design and conduct clinical trials to advance the field of cardiovascular (CV) cell-based therapy. The Cardiovascular Cell Therapy Network successfully completed three clinical trials involving approximately 300 subjects across five centers and six satellites. Although the concept of a network within clinical trials research is not new, the knowledge gained in the implementation of such large-scale trials, particularly in novel therapeutic areas such as cell therapy is not often detailed in the literature. The purpose of this communication is to summarize key factors in achieving network goals and share the knowledge gained to promote success in future cardiovascular disease cell therapy trials and networks.

Original language	English (US)
Pages (from-to)	1495-1502
Number of pages	8
Journal	Expert review of cardiovascular therapy
Volume	11
Issue number	11
DOIs	https://doi.org/10.1586/14779072.2013.839943
State	Published - 2013
Externally published	Yes

Bibliographical note

Funding Information:
The authors were partially supported through funding received by the CCTRN provided by the NHLBI under cooperative agreement 5 UM1 HL087318-07. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Keywords

FOCUS
LateTIME
TIME
acute myocardial infarction
cardiovascular cell therapy network
cardiovascular disease
heart failure
network
stem cell therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1586/14779072.2013.839943

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Park, K. E., Moyé, L. A., Henry, T. D., Perin, E. C., Sayre, S. L., Bettencourt, J., Vojvodic, R. W., Olson, R. E., & Pepine, C. J. (2013). Implementation of Cardovascular Cell Therapy Network trials: Challenges, innovation and lessons learned from experience in the CCTRN. Expert review of cardiovascular therapy, 11(11), 1495-1502. https://doi.org/10.1586/14779072.2013.839943

Implementation of Cardovascular Cell Therapy Network trials : Challenges, innovation and lessons learned from experience in the CCTRN. / Park, Ki E.; Moyé, Lemuel A.; Henry, Timothy D.; Perin, Emerson C.; Sayre, Shelly L.; Bettencourt, Judy; Vojvodic, Rachel W.; Olson, Rachel E.; Pepine, Carl J.

In: Expert review of cardiovascular therapy, Vol. 11, No. 11, 2013, p. 1495-1502.

Research output: Contribution to journal › Review article › peer-review

Park, Ki E. ; Moyé, Lemuel A. ; Henry, Timothy D. ; Perin, Emerson C. ; Sayre, Shelly L. ; Bettencourt, Judy ; Vojvodic, Rachel W. ; Olson, Rachel E. ; Pepine, Carl J. / Implementation of Cardovascular Cell Therapy Network trials : Challenges, innovation and lessons learned from experience in the CCTRN. In: Expert review of cardiovascular therapy. 2013 ; Vol. 11, No. 11. pp. 1495-1502.

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note = "Funding Information: The authors were partially supported through funding received by the CCTRN provided by the NHLBI under cooperative agreement 5 UM1 HL087318-07. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

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Implementation of Cardovascular Cell Therapy Network trials: Challenges, innovation and lessons learned from experience in the CCTRN

Abstract

Bibliographical note

Keywords

UN SDGs

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